UniProt Accession

 PGAM5_MOUSE; Q8BX10; B2RSM6; Q3UK19; Q80VY8; Q8BM78; Q9CZU2 

Genbank Protein ID

 AK012159; AK034588; AK049246; AK146216; AK169643; BC052179; BC138924; BC138925 

Genbank Nucleotide ID

 BAB28067.1; BAC28763.1; BAC33634.1; BAE26984.1; BAE41272.1; AAH52179.1; AAI38925.1; AAI38926.1 

Protein Name

 Serine/threonine-protein phosphatase PGAM5, mitochondrial 

Protein Synonyms/Alias

 Phosphoglycerate mutase family member 5 

Gene Name

 Pgam5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
92	TSRLDHYKAKATRHI	acetylation	[1]
190	DPPVSHWKPEAVYYE	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. 

Sequence Annotation

 REGION 76 81 Interaction with KEAP1 (By similarity).
 MOD_RES 79 79 Phosphoserine (By similarity).
 MOD_RES 115 115 N6-acetyllysine (By similarity).
 MOD_RES 143 143 N6-acetyllysine (By similarity).
 MOD_RES 190 190 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Hydrolase; Membrane; Mitochondrion; Mitochondrion outer membrane; Necrosis; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:EC. 

Interpro

 IPR013078; His_Pase_superF_clade-1. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS