UniProt Accession

 CIR1_HUMAN; Q86X95; A6NFI6; A8K8M4; O95367; Q12804; Q4G1B9; Q6PJI4; Q8IWI2 

Genbank Protein ID

 AF098297; U03644; AK292389; AC018470; BC015040; BC021175; BC038987; BC046098 

Genbank Nucleotide ID

 AAD05243.1; AAA17853.1; BAF85078.1; AAY24216.1; AAH21175.1; AAH38987.1; AAH46098.1 

Protein Name

 Corepressor interacting with RBPJ 1 

Protein Synonyms/Alias

 CBF1-interacting corepressor; Recepin 

Gene Name

 CIR1 

Gene Synonyms/Alias

 CIR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	LMGDERVKNGLNFMY	ubiquitination	[1]
182	RNSGFALKRNVLGRN	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. 

Sequence Annotation

 REGION 1 121 Interaction with RBPJ.
 REGION 204 232 Interaction with RP9 (By similarity).
 MOTIF 235 245 Nuclear localization signal (Potential).
 MOTIF 291 298 Nuclear localization signal (Potential).
 MOD_RES 202 202 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 450 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; TAS:BHF-UCL.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR019339; CIR_N_dom. 

Pfam

 PF10197; Cir_N 

SMART

 SM01083; Cir_N 

PROSITE

  

PRINTS