CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031068
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 General transcription factor IIH subunit 3 
Protein Synonyms/Alias
 cDNA FLJ53013, highly similar to TFIIH basal transcription factor complex p34 subunit 
Gene Name
 GTF2H3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15LFMNRSNKLAVIASHubiquitination[1]
33SRFLYPGKNGRLGDFubiquitination[2]
56EFNPSGSKDGKYELLubiquitination[1, 3]
59PSGSKDGKYELLTSAubiquitination[3]
80EIKDLMTKSDIKGQHubiquitination[3]
84LMTKSDIKGQHTETLubiquitination[1, 2, 3, 4, 5]
98LLAGSLAKALCYIHRubiquitination[4]
111HRMNKEVKDNQEMKSubiquitination[3]
257ISLPPVLKAKKKKLKubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 267 AA 
Protein Sequence
MVLGNSHLFM NRSNKLAVIA SHIQESRFLY PGKNGRLGDF FGDPGNPPEF NPSGSKDGKY 60
ELLTSANEVI VEEIKDLMTK SDIKGQHTET LLAGSLAKAL CYIHRMNKEV KDNQEMKSRI 120
LVIKAAEDSA LQYMNFMNVI FAAQKQNILI DACVLDSDSG LLQQACDITG GLYLKVPQMP 180
SLLQYLLWVF LPDQDQRSQL ILPPPVHVDY RAACFCHRNL IEIGYVCSVC LSIFCNFSPI 240
CTTCETAFKI SLPPVLKAKK KKLKVSA 267 
Gene Ontology
 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR004600; TFIIH_Tfb4/p34. 
Pfam
 PF03850; Tfb4 
SMART
  
PROSITE
  
PRINTS