CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016789
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 von Willebrand factor A domain-containing protein 8 
Protein Synonyms/Alias
  
Gene Name
 Vwa8 
Gene Synonyms/Alias
 Kiaa0564 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
220KLLQDHTKEELDAWKacetylation[1]
508VSAAREGKLVLLDGIacetylation[1]
670RISRRLSKYPSENLHacetylation[1]
988NIVKHLQKFPTEGLSacetylation[1]
1037PTNVQLAKE******acetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
 DOMAIN 1714 1896 VWFA.
 NP_BIND 446 453 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1905 AA 
Protein Sequence
MQSRLLLLGA PGGLGDVASR RVRLLLRQVL RGRPGGDQQR LEVRLLHSGA TDSGETVSIG 60
DVSYKLKTPK NPELVPQNYI SDSPAQSIVQ HLRWLMQKDL LGQDVFLIGP PGPLRRSVAM 120
QYLELTKREV EYIALSRDTT ETDLKQRREI RAGTAFYIDQ CAVRAATEGR TLVLEGLEKA 180
ERNVLPVLNN LLENREMQLE DGRFLMSAER YDKLLQDHTK EELDAWKIVR VSENFRVIAL 240
GLPVPRYSGN PLDPPLRSRF QARDIYFLPF QDQLKLLYSV GANVSAEKIS QLLSFATTLC 300
SQESSTLGLP DFPLDSLPEA VQILDSFPMM SIEHALQWVY PYTLLLGHEG KMAVEGVLKR 360
FELQGSGHSL LPKEIVRVER MTDSHGSYAH VTIRVAGKEV TIKVPAGTRA VNQPCAPDHF 420
IQTVSHKQLL AEMVQSHMVK DICLIGGKGC GKTVIAKNFA ALLGYSIEPI MLYQDMTARD 480
LLQQRYTLPN GDTAWRSSPL VSAAREGKLV LLDGIHRVNA GTLAVLQRLI HDRELSLYDG 540
SRLLREDRYL SLKEKLQLTD EQLQNRSIFP IHPSFRIIAL AEPPIVGSTT QQWLGPEFLT 600
MFFFHHMKPL VKSEEIQVIK ETVPNVPQEA LEKLLSVTHK LRETQDPTAQ SLAASLSTRQ 660
LLRISRRLSK YPSENLHDAI TKACLSRFLP SLAQSALEKN LADAAIETNT EDSLEPELEN 720
YKCEVVAGSL KIGAVSVPVH NAHEKMKVPD VLFYDNVQHM VVMEDMLKDF VLGEHLLLVG 780
NQGVGKNKIV DRFLHLLNRP REYIQLHRDT TVQSLTLQPT VKGGLIVYED SPLVKAVKLG 840
HILVVDEADK APTNVTCILK TLVENGEMIL ADGRRIVADA ANVDGRENLV AIHPDFRMLA 900
LANRPGFPFL GNDFFGTLGD IFSCHAIDNP KPHSELSMLK QYGPDVPEPV LQKLVAAFGE 960
LRNLADQGII NYPYSTREVV NIVKHLQKFP TEGLSSVVRN VFDFDSYNND MREILMNTLH 1020
KYGIPIGAKP TNVQLAKE 1038 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR027417; P-loop_NTPase.
 IPR002035; VWF_A. 
Pfam
 PF07728; AAA_5 
SMART
 SM00382; AAA
 SM00327; VWA 
PROSITE
 PS00674; AAA
 PS50234; VWFA 
PRINTS