UniProt Accession

 AATM_RAT; P00507; Q64551; Q9QV50 

Genbank Protein ID

 M18467; BC061792; U21158; M12709 

Genbank Nucleotide ID

 AAB54275.1; AAH61792.1; AAC13868.1; AAA41267.1 

Protein Name

 Aspartate aminotransferase, mitochondrial 

Protein Synonyms/Alias

 mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A 

Gene Name

 Got2 

Gene Synonyms/Alias

 Maat 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
73	AYRDDNGKPYVLPSV	acetylation	[1]
82	YVLPSVRKAEAQIAG	acetylation	[1]
90	AEAQIAGKNLDKEYL	acetylation	[1]
94	IAGKNLDKEYLPIGG	acetylation	[1]
122	GENSEVLKSGRFVTV	acetylation	[1]
227	DPRPEQWKEMAAVVK	acetylation	[1]
234	KEMAAVVKKKNLFAF	acetylation	[1]
296	GAFTVVCKDAEEAKR	acetylation	[1]
302	CKDAEEAKRVESQLK	acetylation	[1]
309	KRVESQLKILIRPLY	acetylation	[1]
387	MFCFTGLKPEQVERL	acetylation	[1]
404	EFSVYMTKDGRISVA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). 

Sequence Annotation

 BINDING 65 65 Substrate; via amide nitrogen (By
 BINDING 162 162 Substrate (By similarity).
 BINDING 215 215 Substrate (By similarity).
 BINDING 407 407 Substrate (By similarity).
 MOD_RES 73 73 N6-acetyllysine (By similarity).
 MOD_RES 90 90 N6-acetyllysine (By similarity).
 MOD_RES 94 94 N6-acetyllysine (By similarity).
 MOD_RES 96 96 Nitrated tyrosine (By similarity).
 MOD_RES 159 159 N6-acetyllysine (By similarity).
 MOD_RES 185 185 N6-acetyllysine (By similarity).
 MOD_RES 234 234 N6-acetyllysine (By similarity).
 MOD_RES 279 279 N6-(pyridoxal phosphate)lysine.
 MOD_RES 296 296 N6-acetyllysine (By similarity).
 MOD_RES 309 309 N6-succinyllysine (By similarity).
 MOD_RES 345 345 N6-acetyllysine (By similarity).
 MOD_RES 363 363 N6-acetyllysine (By similarity).
 MOD_RES 396 396 N6-acetyllysine (By similarity).
 MOD_RES 404 404 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Aminotransferase; Cell membrane; Complete proteome; Direct protein sequencing; Lipid transport; Membrane; Mitochondrion; Nitration; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 430 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:RGD.
 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0043204; C:perikaryon; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0016597; F:amino acid binding; IDA:RGD.
 GO:0019899; F:enzyme binding; IDA:RGD.
 GO:0016212; F:kynurenine-oxoglutarate transaminase activity; IEA:EC.
 GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; ISS:UniProtKB.
 GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:EC.
 GO:0005543; F:phospholipid binding; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IMP:RGD.
 GO:0030170; F:pyridoxal phosphate binding; IDA:RGD.
 GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.
 GO:0006531; P:aspartate metabolic process; ISS:UniProtKB.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0015908; P:fatty acid transport; TAS:RGD.
 GO:0006536; P:glutamate metabolic process; ISS:UniProtKB. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR000796; Asp_trans.
 IPR004838; NHTrfase_class1_PyrdxlP-BS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

 PS00105; AA_TRANSFER_CLASS_1 

PRINTS

 PR00799; TRANSAMINASE.