UniProt Accession

 MOG1_HUMAN; Q9HD47; D3DTR6; Q68DI3; Q9BR68; Q9HD48; Q9NRU9; Q9P001; Q9P0P2 

Genbank Protein ID

 AF265205; AF265206; AF168714; AF151070; AF161514; AK290399; CR457206; CR749387; CH471108; CH471108; CH471108; BC006486; BC012552; BC100017 

Genbank Nucleotide ID

 AAG01291.1; AAG01292.1; AAF87316.1; AAF36156.1; AAF29129.1; BAF83088.1; CAG33487.1; CAH18237.1; EAW90064.1; EAW90065.1; EAW90066.1; AAH06486.1; AAH12552.1; AAI00018.1 

Protein Name

 Ran guanine nucleotide release factor 

Protein Synonyms/Alias

 RanGNRF; Ran-binding protein MOG1 

Gene Name

 RANGRF 

Gene Synonyms/Alias

 MOG1; RANGNRF; HSPC165; HSPC236; MDS5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	EAWVLSGKQQIAKEN	ubiquitination	[1, 2]
113	SGKQQIAKENQQVAK	ubiquitination	[2, 3, 4]
120	KENQQVAKDVTLHQA	ubiquitination	[2, 3, 4]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Nucleus; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 186 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0014704; C:intercalated disc; ISS:BHF-UCL.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0017080; F:sodium channel regulator activity; IDA:BHF-UCL.
 GO:2000010; P:positive regulation of protein localization to cell surface; IDA:BHF-UCL.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042391; P:regulation of membrane potential; IDA:BHF-UCL.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL. 

Interpro

 IPR007681; Mog1.
 IPR016123; Mog1/PsbP_a/b/a-sand. 

Pfam

 PF04603; Mog1 

SMART

  

PROSITE

  

PRINTS