CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003070
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquinone/menaquinone biosynthesis methyltransferase ubiE 
Protein Synonyms/Alias
 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Demethylmenaquinone methyltransferase 
Gene Name
 ubiE 
Gene Synonyms/Alias
 yigO; b3833; JW5581 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
4****MVDKSQETTHFacetylation[1]
18FGFQTVAKEQKADMVacetylation[1]
21QTVAKEQKADMVAHVacetylation[1]
80GTGDLTAKFSRLVGEacetylation[1]
102DINESMLKMGREKLRacetylation[1]
173LLVLEFSKPIIEPLSacetylation[1]
181PIIEPLSKAYDAYSFacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). 
Sequence Annotation
  
Keyword
 Complete proteome; Menaquinone biosynthesis; Methyltransferase; Reference proteome; Transferase; Ubiquinone biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 251 AA 
Protein Sequence
MVDKSQETTH FGFQTVAKEQ KADMVAHVFH SVASKYDVMN DLMSFGIHRL WKRFTIDCSG 60
VRRGQTVLDL AGGTGDLTAK FSRLVGETGK VVLADINESM LKMGREKLRN IGVIGNVEYV 120
QANAEALPFP DNTFDCITIS FGLRNVTDKD KALRSMYRVL KPGGRLLVLE FSKPIIEPLS 180
KAYDAYSFHV LPRIGSLVAN DADSYRYLAE SIRMHPDQDT LKAMMQDAGF ESVDYYNLTA 240
GVVALHRGYK F 251 
Gene Ontology
 GO:0043333; F:2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IMP:EcoCyc.
 GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; ISS:EcoCyc.
 GO:0009234; P:menaquinone biosynthetic process; IMP:EcoCyc.
 GO:0006744; P:ubiquinone biosynthetic process; IMP:EcoCyc. 
Interpro
 IPR004033; UbiE/COQ5_MeTrFase.
 IPR023576; UbiE/COQ5_MeTrFase_CS.
 IPR025765; UbiE/COQ5_MeTrFase_dom. 
Pfam
 PF01209; Ubie_methyltran 
SMART
  
PROSITE
 PS01183; UBIE_1
 PS01184; UBIE_2 
PRINTS