CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005366
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Delta(24(24(1)))-sterol reductase 
Protein Synonyms/Alias
 C-24(28) sterol reductase; Sterol Delta(24(28))-reductase 
Gene Name
 ERG4 
Gene Synonyms/Alias
 YGL012W; YGL022 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
8MAKDNSEKLQVQGEEubiquitination[1]
16LQVQGEEKKSKQPVNubiquitination[1]
19QGEEKKSKQPVNFLPubiquitination[1]
368SGDKTGRKTFPFLPYubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 473 AA 
Protein Sequence
MAKDNSEKLQ VQGEEKKSKQ PVNFLPQGKW LKPNEIEYEF GGTTGVIGML IGFPLLMYYM 60
WICAEFYHGK VALPKAGESW MHFIKHLYQL VLENGIPEKY DWTIFLTFWV FQIIFYYTLP 120
GIWTKGQPLS HLKGKQLPYF CNAMWTLYVT TTLVLVLHFT NLFRLYVIID RFGRIMTCAI 180
ISGFAFSIIL YLWTLFISHD YHRMTGNHLY DFFMGAPLNP RWGILDLKMF FEVRLPWFTL 240
YFITLGACLK QWETYGYVTP QLGVVMLAHW LYANACAKGE ELIVPTWDMA YEKFGFMLIF 300
WNIAGVPYTY CHCTLYLYYH DPSEYHWSTL YNVSLYVVLL CAYYFFDTAN AQKNAFRKQM 360
SGDKTGRKTF PFLPYQILKN PKYMVTSNGS YLLIDGWYTL ARKIHYTADW TQSLVWALSC 420
GFNSVFPWFF PVFFLVVLIH RAFRDQAKCK RKYGKDWDEY CKHCPYVFIP YVF 473 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0000246; F:delta24(24-1) sterol reductase activity; IDA:SGD.
 GO:0006696; P:ergosterol biosynthetic process; IMP:SGD. 
Interpro
 IPR001171; Ergosterol_biosynth_ERG4_ERG24.
 IPR018083; Sterol_reductase_CS. 
Pfam
 PF01222; ERG4_ERG24 
SMART
  
PROSITE
 PS01017; STEROL_REDUCT_1
 PS01018; STEROL_REDUCT_2 
PRINTS