| Tag | Content |
|---|
| CPLM ID | CPLM-017534 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein SCAI |
Protein Synonyms/Alias | Suppressor of cancer cell invasion protein |
Gene Name | SCAI |
Gene Synonyms/Alias | C9orf126 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 80 | DIPQGERKTVTDFCY | ubiquitination | [1] | | 91 | DFCYLLDKSKQLFNG | ubiquitination | [1] | | 123 | RTFDVYTKLWKFQQQ | ubiquitination | [1] | | 428 | INGDAIHKRNQSHKE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. |
Sequence Annotation | REGION 1 212 Necessary to inhibit MKL1-induced SRF
REGION 71 173 Required for interaction with MKL1 (By
MOD_RES 64 64 Phosphotyrosine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Signal transduction inhibitor; Transcription; Transcription regulation; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 606 AA |
Protein Sequence | MVRGARQPQQ PRSRLAPRLT GTVEKPPRKR RSSIRGSGDS SHSQSQGERY QHFTEKTEFA 60
LKEIMSSGGA EDDIPQGERK TVTDFCYLLD KSKQLFNGLR DLPQYGQKQW QSYFGRTFDV 120
YTKLWKFQQQ HRQVLDNRYG LKRWQIGEIA SKIGQLYYHY YLRTSETSYL NEAFSFYSAI 180
RQRSYYSQVN KEDRPELVVK KLRYYARFIV VCLLLNKMDV VKDLVKELSD EIEDYTHRFN 240
TEDQVEWNLV LQEVAAFIEA DPVMVLNDDN TIVITSNRLA ETGAPLLEQG MIVGQLSLAD 300
ALIIGNCNNQ VKFSELTVDM FRMLQALERE PMNLASQMNK PGMQESADKP TRRENPHKYL 360
LYKPTFSQLY TFLAASFKEL PANSVLLIYL SATGVFPTGR SDSEGPYDFG GVLTNSNRDI 420
INGDAIHKRN QSHKEMHCLH PGDLYPFTRK PLFIIVDSSN SVAYKNFTNL FGQPLVCLLS 480
PTAYPKALQD QSQRGSLFTL FLNNPLMAFL FVSGLSSMRR GLWEKCQEYL RKINRDIAQL 540
LTHSRSIDQA FLQFFGDEFL RLLLTRFIFC SATMRMHKIF RETRNYPESY PQLPRDETVE 600
NPHLQKHILE LASILDVRNV FFENTIDDY 629 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003714; F:transcription corepressor activity; IMP:UniProtKB. GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB. GO:0035024; P:negative regulation of Rho protein signal transduction; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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