| Tag | Content |
|---|
| CPLM ID | CPLM-013175 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin carboxyl-terminal hydrolase 48 |
Protein Synonyms/Alias | Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48 |
Gene Name | Usp48 |
Gene Synonyms/Alias | Kiaa4202 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 708 | KLQQYFPKAPEFPSY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (By similarity). |
Sequence Annotation | DOMAIN 459 553 DUSP 1.
DOMAIN 568 691 DUSP 2.
DOMAIN 710 841 DUSP 3.
DOMAIN 946 1026 Ubiquitin-like.
ACT_SITE 98 98 Nucleophile (By similarity).
ACT_SITE 353 353 Proton acceptor (By similarity).
MOD_RES 903 903 Phosphoserine (By similarity).
MOD_RES 904 904 Phosphoserine.
MOD_RES 905 905 Phosphoserine.
MOD_RES 973 973 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Protease; Reference proteome; Repeat; Thiol protease; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1052 AA |
Protein Sequence | MVGPCPFGRR RRRRRRPPGS ASATSVKAMA PRLQLEKAAW RWAETVRPEE VSQEHIETAY 60
RIWLEPCIRG VCRRNCRGNP NCLVGIGEHI WLGEIDENSF HSIDDPNCER RKKNSFVGLT 120
NLGATCYVNT FLQVWFLNLE LRQALYLCPS TCSDYTKGDG IHGGKDYEPQ TICEHLQYLF 180
ALLQNSNRRY IDPSGFVKAL GLDTGQQQDA QEFSKLFMSL LEDTLSKQKN PDVRNVVQQQ 240
FCGEYAYVTV CNQCGRESKL VSKFYELELN IQGHKQLTDC ISEFLKEERL EGDNRYFCEN 300
CQSKQNATRK IRLLSLPCTL NLQLMRFVFD RQTGHKKKLN AYIGFSESLD MEPYVEHKGG 360
SFVYELSAVL IHRGVSAYSG HYIAHVKDPQ SGEWYKFNDE DIEKMEGKKL QLGIEEDLEP 420
SKSQTRKPKC GKGTHCSRNA YMLVYRLQAQ EKNHTMVQVP AFLQELVDRD NSKFEEWCVE 480
MAEMRKQSVD KGKAKHEEVK ELYQRLPAGA EPYEFVSLEW LQKWLDESTP TKPIDNNACL 540
CSHDKLHPDK ISIMKRISEY AANIFYSRYG GGPRLTVKAL CKDCVVERCR VLRLKNQLNE 600
DYKAVNNLLK STMKGDGFWV GKSSLRSWRQ LALEQLDEQD GEAEQSNGKI NGSTFNKDES 660
KEEKKEEEEE LNFNEDILCP HGELSISENE RRLVSQEAWS KLQQYFPKAP EFPSYRECCS 720
QCKILEREGE ENEALHKMIA NEQKTSLPNL FQDKNRPCLS NWPEDTDALY IVSHFFLDEW 780
RKFVRKPARS APVSSIGNAA LLCPHGGLMF TFPSLTKEDS KLCQPLERRE GGWPTAAHNN 840
IALIWPSEWQ MIQKLFVVDK VIKITRIEVG DVNPSQTQYI SEPSLCPDCR EGLLCQQQRD 900
LREYTQATIY VHKVVDNKKV MKDSAPELNV SSSETEEDKE EAKPDGEKDP DFNQSNGSTK 960
RQKTSQQGYV AYQKQVIRRS TRHRKVRGEK ALLVSANQTL KELKIQIMHA FSVAPFDQNL 1020
SIDGKILNDD CATLGTLGVI PESVILLKAD EPIADYAAMD DVMQVCMPEE GFKGTGLLGH 1080 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW. GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |