| Tag | Content |
|---|
| CPLM ID | CPLM-010947 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin-1 |
Protein Synonyms/Alias | ANK-1; Erythrocyte ankyrin |
Gene Name | Ank1 |
Gene Synonyms/Alias | Ank-1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 73 | VRRRVFLKGDELQNI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. In skeletal muscle, isoform Mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils. |
Sequence Annotation | REPEAT 40 69 ANK 1.
REPEAT 73 102 ANK 2.
REPEAT 106 135 ANK 3.
REPEAT 139 168 ANK 4.
REPEAT 170 197 ANK 5.
REPEAT 201 230 ANK 6.
REPEAT 234 263 ANK 7.
REPEAT 267 296 ANK 8.
REPEAT 300 329 ANK 9.
REPEAT 333 362 ANK 10.
REPEAT 366 395 ANK 11.
REPEAT 399 428 ANK 12.
REPEAT 432 461 ANK 13.
REPEAT 465 494 ANK 14.
REPEAT 498 527 ANK 15.
REPEAT 531 560 ANK 16.
REPEAT 564 593 ANK 17.
REPEAT 597 626 ANK 18.
REPEAT 630 659 ANK 19.
REPEAT 663 692 ANK 20.
REPEAT 696 725 ANK 21.
REPEAT 729 758 ANK 22.
REPEAT 762 791 ANK 23.
DOMAIN 907 1032 ZU5 1.
DOMAIN 1033 1196 ZU5 2.
DOMAIN 1399 1483 Death.
REGION 1 827 89 kDa domain.
REGION 1197 1331 UPA domain (By similarity).
REGION 1387 1862 55 kDa regulatory domain.
MOD_RES 101 101 (3S)-3-hydroxyasparagine; by HIF1AN;
MOD_RES 229 229 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 427 427 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 460 460 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 625 625 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 658 658 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 691 691 (3S)-3-hydroxyaspartate; by HIF1AN (By
MOD_RES 724 724 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 757 757 (3S)-3-hydroxyasparagine; by HIF1AN (By
MOD_RES 852 852 Phosphoserine.
MOD_RES 862 862 Phosphothreonine.
MOD_RES 1069 1069 Phosphotyrosine. |
Keyword | Alternative promoter usage; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydroxylation; Lipoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Sarcoplasmic reticulum. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1862 AA |
Protein Sequence | MWTFITQLLV TLVLLGFFLV SCQNVMHIVK GSLCFVLKHI HQELDKELGE SEGLSDDEET 60
ISTRVVRRRV FLKGDELQNI PGEQVTEEQF TDEQGNIVTK KIIRKVVRQV DSSGAIDTQQ 120
HEEVELRGSG LQPDLIEGRK GAQIVKRASL KRGKQ 155 |
Gene Ontology | GO:0030863; C:cortical cytoskeleton; IDA:MGI. GO:0016020; C:membrane; IDA:MGI. GO:0005886; C:plasma membrane; IEA:Compara. GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0014731; C:spectrin-associated cytoskeleton; IMP:MGI. GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Compara. GO:0048821; P:erythrocyte development; IMP:MGI. GO:0015672; P:monovalent inorganic cation transport; IMP:MGI. GO:0006779; P:porphyrin-containing compound biosynthetic process; IMP:MGI. GO:0072661; P:protein targeting to plasma membrane; IEA:Compara. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |