CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012021
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 
Protein Synonyms/Alias
 Multisynthase complex auxiliary component p38; Protein JTV-1 
Gene Name
 AIMP2 
Gene Synonyms/Alias
 JTV1; PRO0992 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MPMYQVKPYHGGGAubiquitination[1, 2]
70LKRLYELKAAVDGLSubiquitination[3, 4]
159VHTHSSVKSVPENLLubiquitination[3]
317APFNTALKLLK****ubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. 
Sequence Annotation
 DOMAIN 220 317 GST C-terminal.
 REGION 82 162 Interaction with PARK2.
 REGION 162 225 Interaction with TP53.  
Keyword
 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Nucleus; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 320 AA 
Protein Sequence
MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL SLQALESRQD 60
DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT LTTNALDLNS VLGKDYGALK 120
DIVINANPAS PPLSLLVLHR LLCEHFRVLS TVHTHSSVKS VPENLLKCFG EQNKKQPRQD 180
YQLGFTLIWK NVPKTQMKFS IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA 240
IFQLKEGSSK EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ 300
RWMRSCENLA PFNTALKLLK 320 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0031398; P:positive regulation of protein ubiquitination; IEA:Compara.
 GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome.
 GO:0060510; P:Type II pneumocyte differentiation; IEA:Compara. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like. 
Pfam
  
SMART
  
PROSITE
 PS50405; GST_CTER 
PRINTS