CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015571
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoinositide 3-kinase adapter protein 1 
Protein Synonyms/Alias
 B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1 
Gene Name
 PIK3AP1 
Gene Synonyms/Alias
 BCAP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
487TKDSMIRKFLEGNSMubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. 
Sequence Annotation
 DOMAIN 181 317 DBB.
 REGION 10 144 Necessary and sufficent to mediate
 MOD_RES 263 263 Phosphotyrosine (By similarity).
 MOD_RES 419 419 Phosphotyrosine; by SYK (By similarity).
 MOD_RES 444 444 Phosphotyrosine; by SYK (By similarity).
 MOD_RES 459 459 Phosphotyrosine; by SYK (By similarity).
 MOD_RES 513 513 Phosphotyrosine; by ABL1.
 MOD_RES 553 553 Phosphotyrosine; by ABL1.
 MOD_RES 570 570 Phosphotyrosine; by ABL1.
 MOD_RES 594 594 Phosphotyrosine; by ABL1.
 MOD_RES 694 694 Phosphotyrosine; by ABL1.  
Keyword
 Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 805 AA 
Protein Sequence
MAASGVPRGC DILIVYSPDA EEWCQYLQTL FLSSRQVRSQ KILTHRLGPE ASFSAEDLSL 60
FLSTRCVVVL LSAELVQHFH KPALLPLLQR AFHPPHRVVR LLCGVRDSEE FLDFFPDWAH 120
WQELTCDDEP ETYVAAVKKA ISEDSGCDSV TDTEPEDEKV VSYSKQQNLP TVTSPGNLMV 180
VQPDRIRCGA ETTVYVIVRC KLDDRVATEA EFSPEDSPSV RMEAKVENEY TISVKAPNLS 240
SGNVSLKIYS GDLVVCETVI SYYTDMEEIG NLLSNAANPV EFMCQAFKIV PYNTETLDKL 300
LTESLKNNIP ASGLHLFGIN QLEEEDMMTN QRDEELPTLL HFAAKYGLKN LTALLLTCPG 360
ALQAYSVANK HGHYPNTIAE KHGFRDLRQF IDEYVETVDM LKSHIKEELM HGEEADAVYE 420
SMAHLSTDLL MKCSLNPGCD EDLYESMAAF VPAATEDLYV EMLQASTSNP IPGDGFSRAT 480
KDSMIRKFLE GNSMGMTNLE RDQCHLGQEE DVYHTVDDDE AFSVDLASRP PVPVPRPETT 540
APGAHQLPDN EPYIFKVFAE KSQERPGNFY VSSESIRKGP PVRPWRDRPQ SSIYDPFAGM 600
KTPGQRQLIT LQEQVKLGIV NVDEAVLHFK EWQLNQKKRS ESFRFQQENL KRLRDSITRR 660
QREKQKSGKQ TDLEITVPIR HSQHLPAKVE FGVYESGPRK SVIPPRTELR RGDWKTDSTS 720
STASSTSNRS STRSLLSVSS GMEGDNEDNE VPEVTRSRSP GPPQVDGTPT MSLERPPRVP 780
PRAASQRPPT RETFHPPPPV PPRGR 805 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0036312; F:phosphatidylinositol 3-kinase regulatory subunit binding; ISS:UniProtKB.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
 GO:0034134; P:toll-like receptor 2 signaling pathway; ISS:UniProtKB.
 GO:0034142; P:toll-like receptor 4 signaling pathway; ISS:UniProtKB.
 GO:0034154; P:toll-like receptor 7 signaling pathway; ISS:UniProtKB.
 GO:0034162; P:toll-like receptor 9 signaling pathway; ISS:UniProtKB. 
Interpro
 IPR017893; DBB_domain. 
Pfam
  
SMART
  
PROSITE
 PS51376; DBB 
PRINTS