UniProt Accession

 D3Z227_MOUSE; D3Z227 

Genbank Protein ID

 AC133487 

Genbank Nucleotide ID

  

Protein Name

 Catechol O-methyltransferase 

Protein Synonyms/Alias

  

Gene Name

 Comt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	RHVQQHAKPGDPQSV	ubiquitination	[1]
170	QDLIPQLKK******	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016206; F:catechol O-methyltransferase activity; IDA:MGI.
 GO:0042420; P:dopamine catabolic process; IDA:MGI.
 GO:0008210; P:estrogen metabolic process; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0007612; P:learning; IEA:Compara.
 GO:0048609; P:multicellular organismal reproductive process; IEA:Compara.
 GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0050668; P:positive regulation of homocysteine metabolic process; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0048265; P:response to pain; IEA:Compara. 

Interpro

 IPR025782; Catechol_O-MeTrfase.
 IPR002935; O-MeTrfase_3. 

Pfam

 PF01596; Methyltransf_3 

SMART

  

PROSITE

 PS51557; SAM_MT_CATECHOL 

PRINTS