CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neuronal guanine nucleotide exchange factor (Predicted) 
Protein Synonyms/Alias
 Protein LOC100912512 
Gene Name
 LOC100912512 
Gene Synonyms/Alias
 Ngef_predicted; rCG_23807 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
93LYQEYRDKSTLQEIEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 616 AA 
Protein Sequence
MELLAAAFSA ACAVDHDSST SESDTRDSAA GHLPGSESSS TPGNGTTPEE CPALTDSPTT 60
LTEALQMIHP IPADSWRNLI EQIGLLYQEY RDKSTLQEIE TRRQQDAEIQ GNSDGSQAGE 120
DNAEEEEEEE EEPASPPERR ALPQICLLSN PHSRFNLWQD LPEIQSSGVL DILQPEETKL 180
QEAMFELVTS EASYYKSLNL LVSHFMENER LKKILHPSEA HILFSNVLDV MAVSERFLLE 240
LEHRMEENIV ISDVCDIVYR YAADHFSVYI TYVSNQTYQE RTYKQLLQEK TAFRELIAQL 300
ELDPKCKGLP LSSFLILPFQ RITRLKLLVQ NILKRVEEGS EREGTALDAH KELEMVVKAC 360
NEGVRKMSRT EQMISIQKKM EFKIKSVPII SHSRWLLKQG ELQQMSGPKT SRTLRTKKLF 420
REIYLFLFND LLVICRQIPG DKYQVFDSAP RGLLRVEELE DQGQTLANVF ILRLLENADD 480
REATYMLKAS SQSEMKRWMT SLAPNRRTKF VSFTSRLLDC PQVQCVHPYV AQQPDELTLE 540
LADILNILEK TEDGWIFGER LHDQERGWFP SSMTEEILNP KIRSQNLKEC FRVHKMEDPQ 600
RSQNKDRRKL GSRNRQ 616 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0009987; P:cellular process; IEA:Compara.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001452; SH3_domain. 
Pfam
 PF00621; RhoGEF
 PF00018; SH3_1 
SMART
 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS