CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043232
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Aflatoxin B1 aldehyde reductase member 2 
Protein Synonyms/Alias
  
Gene Name
 AKR7A2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95CRVKIATKANPWDGKubiquitination[1, 2]
102KANPWDGKSLKPDSVubiquitination[1, 2]
105PWDGKSLKPDSVRSQubiquitination[1]
118SQLETSLKRLQCPQVubiquitination[1, 3]
191AGGLLTGKYKYEDKDubiquitination[1, 3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR MDAPASAAAV RAFLERGHTE 60
LDTAFMYSDG QSETILGGLG LGLGGGDCRV KIATKANPWD GKSLKPDSVR SQLETSLKRL 120
QCPQVDLFYL HAPDHGTPVE ETLHACQRLH QEGMYNATTR QVETELFPCL RHFGLRFYAY 180
NPLAGGLLTG KYKYEDKDGK QPVGRFFGNS WAETYRNRFW KEHHFEAIAL VEKALQAAYG 240
ASAPSVTSAA LRWMYHHSQL QGAHGDAVIL GMSSLEQLEQ NLAATEEGPL EPAVVDAFNQ 300
AWHLVAHECP NYFR 314 
Gene Ontology
  
Interpro
 IPR001395; Aldo/ket_red.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
  
PRINTS