CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033499
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 IQ motif and SEC7 domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 IQSEC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138FRQYQMNKNFERLRSubiquitination[1]
234DAFSRQVKSLAESIDubiquitination[1]
670MKLEDFIKNLRGVDDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1160 AA 
Protein Sequence
MACRRRYFVE GEAPSSETGT SLDSPSAYPQ GPLVPGSSLS PDHYEHTSVG AYGLYSGPPG 60
QQQRTRRPKL QHSTSILRKQ AEEEAIKRSR SLSESYELSS DLQDKQVEML ERKYGGRLVT 120
RHAARTIQTA FRQYQMNKNF ERLRSSMSEN RMSRRIVLSN MRMQFSFEGP EKVHSSYFEG 180
KQVSVTNDGS QLGALVSPEC GDLSEPTTLK SPAPSSDFAD AITELEDAFS RQVKSLAESI 240
DDALNCRSLH TEEAPALDAA RARDTEPQTA LHGMDHRKLD EMTASYSDVT LYIDEEELSP 300
PLPLSQAGDR PSSTESDLRL RAGGAAPDYW ALAHKEDKAD TDTSCRSTPS LERQEQRLRV 360
EHLPLLTIEP PSDSSVDLSD RSERGSLKRQ SAYERSLGGQ QGSPKHGPHS GAPKSLPREE 420
PELRPRPPRP LDSHLAINGS ANRQSKSESD YSDGDNDSIN STSNSNDTIN CSSESSSRDS 480
LREQTLSKQT YHKEARNSWD SPAFSNDVIR KRHYRIGLNL FNKKPEKGVQ YLIERGFVPD 540
TPVGVAHFLL QRKGLSRQMI GEFLGNRQKQ FNRDVLDCVV DEMDFSTMEL DEALRKFQAH 600
IRVQGEAQKV ERLIEAFSQR YCICNPGVVR QFRNPDTIFI LAFAIILLNT DMYSPNVKPE 660
RKMKLEDFIK NLRGVDDGED IPREMLMGIY ERIRKRELKT NEDHVSQVQK VEKLIVGKKP 720
IGSLHPGLGC VLSLPHRRLV CYCRLFEVPD PNKPQKLGLH QREIFLFNDL LVVTKIFQKK 780
KNSVTYSFRQ SFSLYGMQVL LFENQYYPNG IRLTSSVPGA DIKVLINFNA PNPQDRKKFT 840
DDLRESIAEV QEMEKHRIES ELEKQKGVVR PSMSQCSSLK KESGNGTLSR ACLDDSYASG 900
EGLKRSALSS SLRDLSEAGK RGRRSSAGSL ESNVEGSIIS SPHMRRRATS TRECPSRPHQ 960
TMPNSSSLLG SLFGSKRGKP PPQAHLPSAP ALATPPPTGG PASLAALCGW PPPGAPRGAA 1020
AGRHARASHP VLPHAEPSPV PPSPPPPPTP AHPARTPVPP RPPWGPPSLR GPCPRPPAAA 1080
LGPRGAHSAP PWAAPCPAAP HQQQGQTQRH QHNCVDSLGR GPRLPETPAH HTGHARGSPA 1140
AHQTRGTSVA ISPLCPSRPN 1160 
Gene Ontology
 GO:0030054; C:cell junction; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000904; Sec7.
 IPR023394; SEC7_alpha_orthog. 
Pfam
 PF01369; Sec7 
SMART
 SM00233; PH
 SM00222; Sec7 
PROSITE
 PS50096; IQ
 PS50190; SEC7 
PRINTS