CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039425
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp47 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
102ANFEPGKKNFLHLTDacetylation[1]
690DQIFQSYKPGEVMVKacetylation[1]
762SMPSKTLKAEGFFRSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1355 AA 
Protein Sequence
MVPGEENQLV PKEIENAAEE PRVLCIIQDT TNSKTVNERI TVNLPASTPV RKLFEDVANK 60
VGYINGTFDL TWGNGINTAD LAPLDHTSDK SLLDANFEPG KKNFLHLTDK DGEQPQMLLD 120
DSSHVDDSVH DRFIGPLPRE GSVASTSDYV SQSYSYSSIL NKSETGYVGL VNQAMTCYLN 180
SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF VLLQTSKKRA IETTDVTRSF 240
GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL YQGKLKDYVR CLECGYEGWR 300
IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN QYFCERCKKK CDARKGLRFL 360
HFPYLLTLQL KRFDFDYTTM HRIKLNDRMS FPEELDMSTF IDIEDEKSPQ TESCTDSGAE 420
NEGSCHSDQM SNDFSTDDAV DEGICLESST GSEKISKPGL EKNSLMYELF SVMVHSGSAA 480
GGHYYACIKS FSDDQWYSFN DQHVSRITQE DIKKTHGGSS GSRGYYSSAF ASSTNAYMLI 540
YRLKDPTRNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR EIERNTCKIK LFCLHPVKQV 600
MMENKLEVHK DKTLKEAVEM AYKMMDLEDV IPLDCCRLVK YDEFHDYLER SYEGEEDTPM 660
GLLLGGVKST YMFDLLLETR KPDQIFQSYK PGEVMVKVHV VDLKAETVAA PVTVRAYLNQ 720
TVLEFKQLIS KATHLPAEPM RIVLERCYND LRLLSMPSKT LKAEGFFRSN KVFVESSETV 780
DHQAAFTDSH LWKLLDRHAN TIRLFVLLPE QSPGSYSKRT AYQKAGGDSG NVDDDCERAK 840
GPAGSLKSVD AILEESTEKL KSLSLQQQQD GDNGDSSKST ETSDFENIES PLNERGSSTS 900
VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD ILSSSHSSDT LCNADSAQIP 960
LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD ESGKSRGEMQ YMYFKADPYT 1020
ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF KVFRVYTSNQ EFETVRLNET 1080
LSSFSDDNKI TIRLGRALKK GEYRVKVCQL LVNEQEPCKF LLDAVFAKGM TVRQSKEELI 1140
PQLREQCGLD LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI NISSNWEVFL EVLDGVEKMK 1200
SMSQLAILTR RWRPSEMKLD PFQELVLESN SVDELREKLS EISGIPLEDI EFAKGRGTFP 1260
CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDR TEEVMELTDE QRNELMKKES 1320
SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DVAQD 1355 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0019005; C:SCF ubiquitin ligase complex; IEA:Compara.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; IEA:Compara.
 GO:0006284; P:base-excision repair; IEA:Compara.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0035520; P:monoubiquitinated protein deubiquitination; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS