CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024839
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 PFC0425w 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
2266NVPVDIQKRNYINTNacetylation[1]
4136KKKKKSSKANNTVSNacetylation[1]
4148VSNATSLKKQEHLLLacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4550 AA 
Protein Sequence
MDGDISRKSY VEILKYYSKD ENKLGGHNFG KNKKKDLNKY DIYYKDYLYD YYKECNNNIN 60
NNSSSYYNKF NTEYTDCLKT DNSFFMTTLS NLKKDNDDND VDCINKGGSY SSNNNNNNFC 120
LNVEMLFSFL FCKKKNYFYN IKNKYFNEKF YQTNNNIKKK RKKKKKKKKK KEKKNVHEDK 180
QIYDEYDDEE ENKNKFLYNI KKYQKKKKYY INKEYYYVKN YYHDIKKNIK LDKQKNNNTC 240
TICFINNNNK YIERCTLCFV HFHVYCYKTY CDDFNLNNFI CDFCKYNIKH NHIYNENKYN 300
QTIHKTNNNN YRYNCFIQKK KKNSYMNQDS LFSNYIDSSH ENDYKKYSFA YPYNYNMNKQ 360
NDDENSKACQ NMNSYDDDQH VCHLKRRIKN KHKWFCKKKN VFEYFTDHDF ISTREYLNKE 420
GGDEKKNKRK RKYIKYNTKG NTKGNTKGNT QENIQNNTQE NIQENIQNNT QNNTQNNTQN 480
NTQNNTQNNT QGNIKDNIIY HMNDLINNHI SDNTPNHIYN VQNKEHPFCS EYIPMYDNEY 540
FSETIYNNNN THLNKCCNIY QEEENMINSF LLKKSSFNKY CDKSNNSLKR KFTDLSKDKE 600
KRIFCMICKN MNTNVLMKKK GKDEWYHVCC LYYNNITRNN CIYHIYVEHF FFNHYNEDYF 660
VNMFGSLKYI NEIIIKKIKD ELLKNYNILA HSHFFNFLMN PYYYNLTFKQ IKNLIFSNFI 720
LNNNTLYSNY QSLSYQSLNQ TRRKRIEESR SISQGNHNEI YGASIKCAQN GVRDNKLDGN 780
HDNDKKDDNK KDGDKKDDNK KDGDKKDDDK KGDDKYDDGD DKYDDDDNKY DDDDDIYDDD 840
DDFNFDHDSE TSKRLSNYDS LLKDKKKGSI LKKEDTLKCS KMINVQEKEK SSKMYCMNTN 900
NCNVVKEKNY FVNDYMHIIN NLSDHEMNIN MMKSPGYNNL FKDVEHFIHK RDFINLNILK 960
LIKEKIIQVL QNNYKQVCVF CKKTTGIKTK CMFPSCSTYF HIYCYYNKYM QHVRKKKNDL 1020
QCASQKKSRK NQRAASVKRR GAEGKDKKDG SRSLDRKKDK VTRRSNKYEE SANDSDGKKN 1080
NGDDKKKGDN IGKNNNNNNN NNDDDSNNNG DDSNNNGDDS NNNGDGNNNI NGDGNNNING 1140
DGNNNINGDG NNNNDCLEEK NQGDNQKKRK RNKRGRNNND DTSSLVLLNK DDSRQKKKNK 1200
YGKDHSDQEK DSPSKINNRS KRNKVKKDKE VGNINDDKIN NNTNDDNKNN NINGDNKNNN 1260
INGDNKNNNI NGDKINNNIN GDKINNNING DKISKNYHSH NYDNEEITHE QKNNFNKNKN 1320
TKRYRKSIND KEMNDILNNK NNDTDKKLNK YNFLMEYQKI ISSDKITSGI SNNMKDIKNI 1380
KDIKDIKDIK NIKDIKDIKD IKDIKDIKDI KNVKNIKDIK SNEDIKDIKD VNDVSSVHLN 1440
KCVNNKSDTQ DFCPSDDKNI NNIIKKNKIN IKTDQVYNPL VDSSSSSTDC NKNYKKKEKA 1500
VKKIGWNIKN IKLHNNNNNN NNNNNNNNNN NNISSNNVVQ EDYKMKGKGS HKKNEKHSTN 1560
YNQDDIYYDN DFSSICSLLS SSLSTNNDID SSYVSNNSLY NSSSMFSNDD CFSLCYSSVS 1620
SSYEYDDINN VNLKNKIHNF PSFYKNELNN NNNNNNNNNN NNNNNECHNY NRKHHCTHSR 1680
DLSCSSRSFW GSLYNTSDNI SESEISNNLS FSSDKSENYC SSISDHEIEK DVTIYRNTYH 1740
RIINRWKDGK KNTGSKKRDM SNKKGDKSCN KKNICDNKKN IYDNKKLIYD NKDSSTDAPV 1800
ENIDHLIEKE EIDNILNNLG LYTYNLKNNN NNNVYMKTIK LTLCCTHSNE HDTKAVMNIK 1860
LNTLNNKKYN NINCIFYHYY NSFLHSLFYS DEYIELIRKE ERKEDIEKEK IKRGKYCHQE 1920
DRDDNMNNND NNDNNNNNDN NNNNDNNNNN DNNNNDNNNN DNNNSGEDQL INEDNKKRKI 1980
NNLSTHEHTH NMSDHNKEPK KKKNKSNETQ INDDTNKKET HKNEIDHKEQ KDTNCDNGIE 2040
EKKDQVSKSN NIISKVFHFF ERKNNNIKKD EHKKEYNERN DKMSECDMLL QNKRDNDHNN 2100
NNNNNNDDDN NNNNNNDDDN NNNNNNNDDH NNNNNNNDDD NNNNNNNDDD NNKDPTLDGE 2160
TRSYIDEINQ KEINIFSKYI DKIIENVETK CIMKNNVCDG IYYLIRQENG LNICQKVNNN 2220
IIKNKMKQEK FYKKKKQNKN NHKNKNKNKY NYDINIFNNV PVDIQKRNYI NTNIININNN 2280
NNNNSNSNHS NHNNNSNHIN LSDLKKKINI NKYTYLFYRL PLFLFGDKYI NDIDDVKSIY 2340
MIKNFFNQYN DVTNTSNNIL YVIDLLKKYN TNHNILKKNN MIQSPKNYIC EKEEQSNDPA 2400
KNTHVPFNHN ALDTSHPPVD TTNTNLLSDV NIETNEIQEH INNNIRNDHN NVINNQQMEP 2460
KNNNTPNEEK IILESTTQRS EQRMEDRDEE DGKSGEDTRL VDVETKVVDV ETKVVDVETK 2520
VVDVETKVVD VETKVVDVET KVTDVETKVT DVDHKMVDVE TKVTDVDHKV VDVDHKVVDV 2580
DHKMVDVDHK MVDVDHKMVD VDHKMVDVDH KMVDVDHKMV DVDHKMVDVD HKVVDVDHNV 2640
VDVQTIDAPN RKPIIDDCMK IKKMKKKKKS ETLVQENELS CYPNKNVNVI FSLFDNGNNC 2700
YLLIYESEKD NKKKSGKNKA LKTKKDYNNI DYFFKDLYHK IHEINLNEGS YKILKDIYFS 2760
MLYNMNNMKN CGIQYLNRMN RHSYNKKVSK GSISSNINNN INNNINNINN NNMNNNMNNN 2820
LINYQHNYNS NNFQYNEEIN YIKFNETILN KNTLNNLLKN FGCLNISKSA HIKLVNILEL 2880
SYYDYIFLKT HKIFFSKKGV KIYDHSNNLY NFQENMNDSV EKNTKETNKL FKKKFRYLSL 2940
KLKNILMSHC AGGLKTNHNK KIGKLKGNST HNNNNRNNYY YNNTLNIRGL ASNNKNNDME 3000
NIIMTYKKNN IIKNETLNIV TNKGLLCLNR EGDHQVRFET PLDININRKY VEKNNNTSHG 3060
ILNMYNMYNM HNMYNTYSVH GIRDKNCNAQ LYNDTNLFNN MKKFPKSGEE NCVEDINQID 3120
SKILTSDQKK NNLNMNKNMK YKNTLSKGVK KTLYCKKKGK NKKGNTNKYN VLIKTASLSS 3180
PLPSYMNTIN LLNNNNNISH NNNNILILLM NEYLLNKDND INDYNIKEYL NEILNKYNKF 3240
NFYENNYDII KYSTFVDHKI VPSVSSFSVF DLYKLFFFDH KELDKINNEQ DKMKYINDVL 3300
FNKNALLNFR NFIMKKKHID YVKKSFNYKN ITDIANSYLI DIYHILSFEK NQKLFFNKIN 3360
NNRPTQEIQT IIHTNKNSTI VYDTNKTEQD VCKILTKTQD HQNNINHTNH VHTNDVKDID 3420
KKKNKKKSVK NVHMDMDHVD DIKSIHVNNT NKMNNTNKMN NTNKMNNTNK MNNTNKMNNT 3480
IQMNNIKINS PNDATPYIHT TTQPYESINC YAGLVRNTCS TDKINTNDVN VKRENVSKND 3540
LQDVKDDNDK TRNGDIGIND EIRRNGDIGI NGNIGINGNI GINGNIGIND DIGINDEIKR 3600
NIPFYINSNN NNNNNNYYYY NNYAYFNIVN QNVHNPYGNL FDNQYKYEDE NFELLINKNY 3660
TNLKNLYDYI SDEIVKNKIY LISNIIEENH TYNISDMPVY VNFVYYKYSC VTNWVNLVNN 3720
LKDSFDKEET FFRKYNIVSK GDMKDKEDTK NQTIKEKGGD IKKKDDIKKK DDIKKDDIKM 3780
DDIKMDDVKD DIKKDDIKKD DIKKDDIKMD DVKDDIKKDD VKDDIKKDDI KMDDVKDDIK 3840
KDDIKKDDIK KDDIKMDDVK DDIKKDDIKK DDIKKDDIKM DDVKDDVKDD IKKDDIKKKD 3900
DIKKDDIKKD DIKMDDVKDD IKKDDIKKKD DIKKDDIKMD DVKDDIKKDD IKKKDDIKKD 3960
DIKMDDVKDD IKKKDDIGQS TYHVKEQNEE VKNVIKTPCP DKCINNDNNI IKTEEKIDEK 4020
KKKEDDNNNN NNNNNNNNNK NKKIESESVE KTSNNMCSVC FNIQDGNINI LYKCTKCNIY 4080
VHKYCYGIYP KNKSEDFLCD KCMFNKYVRK LFSNDDINNN NKSSSTNIKK KKKSSKANNT 4140
VSNATSLKKQ EHLLLTSENN IIIKNDNMNE ENNNINNNND NILSACRDNS NIVTSLQNNH 4200
MNTDIITSLN NNSLHANINN LFYNYCCICK KSGGALKKTT SKTFVHLFCV IFFISNVFCY 4260
NIYNMNYWNV NQLKDYEHVC DICNKTGAVI QCSYDHEKLK SGDNKCGDNK CGDDKCGDDK 4320
CGDDKCGDDK CGDDKCGDDK CGDDKCGDDK CGDDKCGDDK CGDNKCGDNK CGDNKCGDNK 4380
CGDNKCGDNK CGDNKCGDNK CGDNKCGDNK CGDNKCGDNK CGDNKCGDNK CGDNKCGDNK 4440
CGDNKCGDNK CGDNKCGDNN KCKKYYHPLC AYLEGYYMDV EVHDDQYITT FFYDNCFSHI 4500
DIKTYCNDHT PMNSYQDRNI IKETRNKCYE SNNISYMFQI YNNNMMMNKK 4550 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
 SM00249; PHD 
PROSITE
 PS01359; ZF_PHD_1 
PRINTS