CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011515
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein BRE4 
Protein Synonyms/Alias
 Brefeldin A-sensitivity protein 4 
Gene Name
 BRE4 
Gene Synonyms/Alias
 YDL231C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
430SDSATLSKEASASPQubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 May be involved in intracellular vesicle transport. 
Sequence Annotation
 CARBOHYD 830 830 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1125 AA 
Protein Sequence
MKRYERDRSP TPDPDIVKGS YSQTSLRSLH ELNYKNPAGI SGLSFAGSPQ QSVASLSQMR 60
LENLVKDKHW EEVEDFGLEE LRDGFFDAAF TKPDSKARSP NSDIDDDNGA ARKKLQSGFT 120
KLSEYVWTAI YRPIIHFPRD IRKNGVSIFK FFIAYFIAIV ICVIRPSGRW IGHEFRYFLP 180
IAVLIHHPVR NIGVQLEMTI SSIIGASFGL GWSALAWYIS TATKPTANYQ GGILFQSLTM 240
ALLFAIWLRS VYRRFFYFTT SFSISIIFTH TVRLASSKFD LKWQIFWDFG ISYLFGLLLS 300
LLVCVCVSPH SGNAELMEHY NKCLQTTKTF LMALVDTELI KSKEQIYLAQ VKMVKTLNID 360
LSQGFRDFVN QLTISRFDLQ SLKSLRNSLT AMETSLRVLP IAPKIFNDDE LKKMYEELEK 420
YRSDSATLSK EASASPQSSG IPTRENTPSA FKPIGPGLLK NEIYINALKA SFSKSIFNLI 480
LEMIFVLENL SRVLKKYESP NQKNNLDECV KILSHSHSKL KRKIYKLDVC YRDFVNSSFF 540
SQELLNDEES VDIFLFLRYL RNSARQLVTV IHDCQVLGEN IHWRIALPSY PLSRALTRLP 600
KQCVLDEGAG NVLHYFEAKR DVDEIFERVY NTYTSRHKYN KGEEEALRLD SQGGDEKSQN 660
RKNHTISIRA IDHNDFNFHT TQNPWRFKLW KLSRILSGDE CKWTLKITFC MIFLCLPTWL 720
PESYHWYQEF HCWWAPLTFY LLAHRRYSGN WALVMRRLIC GIVGIFWGWA ANQSRHFGSP 780
YVVCTFAGLI VVPFSINFLV YRNTKSSFTA LMCFTIIALE PYSKPNRHYN LTTAGIWKST 840
WVTGLALIIG ILVSIPINWI VWPFRARTEL RDSMSSLLAH LGQSYQTVAD RYLYRDADDA 900
PTDLTFAFSH IREVRLTQSL EAIRELLKKA RHEPIIISNF NPEKYASLIN SCQFLLSKII 960
EARISGAFFE IWDQDFDIET TRALLSLRRD SVSSVIFVFY ILSNCFRSKN KIPRYLPNPI 1020
MSRKKLYHFI KKFSEMKDQS HSNLNSGGNS MEKNLFKKIY QQKASSSGQQ QLPLPSVANS 1080
SEIDSEKMHW TEVHGIAFAR AFTDISEALF QVESCAKDIL GEENF 1125 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR018820; BRE4-related_DUF2421.
 IPR023244; Brefeldin_A-sensitivity_4. 
Pfam
 PF10334; DUF2421 
SMART
  
PROSITE
  
PRINTS
 PR02047; BREFELDNASP4.