[1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
Functional Description
Myosin heavy chain that is required for the cell cycle- regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.
Sequence Annotation
DOMAIN 72 769 Myosin head-like. DOMAIN 784 806 IQ 1. DOMAIN 807 831 IQ 2. DOMAIN 832 855 IQ 3. DOMAIN 856 879 IQ 4. DOMAIN 880 902 IQ 5. DOMAIN 903 932 IQ 6. DOMAIN 1226 1501 Dilute. NP_BIND 164 171 ATP (By similarity). REGION 443 523 Actin-binding (By similarity). REGION 1087 1574 Non alpha-helical, tail domain. MOD_RES 1097 1097 Phosphothreonine. MOD_RES 1121 1121 Phosphoserine.