UniProt Accession

 H7BYZ9_HUMAN; H7BYZ9 

Genbank Protein ID

 AL445423; AL606726 

Genbank Nucleotide ID

  

Protein Name

 MOSC domain-containing protein 1, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 MARC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	PTTNAVHKCRVHGLE	ubiquitination	[1]
83	QWITSFLKSQPYRLV	ubiquitination	[1]
214	DTGVMSRKEPLETLK	ubiquitination	[1]
221	KEPLETLKSYRQCDP	ubiquitination	[1, 2]
232	QCDPSERKLYGKSPL	ubiquitination	[1]
236	SERKLYGKSPLFGQY	ubiquitination	[1, 2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0030151; F:molybdenum ion binding; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR005302; MoCF_Sase_C.
 IPR005303; MOSC_N.
 IPR011037; Pyrv_Knase-like_insert_dom. 

Pfam

 PF03473; MOSC
 PF03476; MOSC_N 

SMART

  

PROSITE

 PS51340; MOSC 

PRINTS