CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028091
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hepatocyte nuclear factor 4, isoform A 
Protein Synonyms/Alias
 RE09535p 
Gene Name
 Hnf4 
Gene Synonyms/Alias
 CG9310; Dmel_CG9310 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
3*****MMKHPQDLSVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 704 AA 
Protein Sequence
MMKHPQDLSV TDDQQLMKVN KVEKMEQELH DPESESHIMH ADALASAYPA ASQPHSPIGL 60
ALSPNGGGLG LSNSSNQSSE NFALCNGNGN AGSAGGGSAS SGSNNNNSMF SPNNNLSGSG 120
SGTNSSQQQL QQQQQQQSPT VCAICGDRAT GKHYGASSCD GCKGFFRRSV RKNHQYTCRF 180
ARNCVVDKDK RNQCRYCRLR KCFKAGMKKE AVQNERDRIS CRRTSNDDPD PGNGLSVISL 240
VKAENESRQS KAGAAMEPNI NEDLSNKQFA SINDVCESMK QQLLTLVEWA KQIPAFNELQ 300
LDDQVALLRA HAGEHLLLGL SRRSMHLKDV LLLSNNCVIT RHCPDPLVSP NLDISRIGAR 360
IIDELVTVMK DVGIDDTEFA CIKALVFFDP NAKGLNEPHR IKSLRHQILN NLEDYISDRQ 420
YESRGRFGEI LLILPVLQSI TWQMIEQIQF AKIFGVAHID SLLQEMLLGG ELADNPLPLS 480
PPNQSNDYQS PTHTGNMEGG NQVNSSLDSL ATSGGPGSHS LDLEVQHIQA LIEANSADDS 540
FRAYAASTAA AAAAAVSSSS SAPASVAPAS ISPPLNSPKS QHQHQQHATH QQQQESSYLD 600
MPVKHYNGSR SGPLPTQHSP QRMHPYQRAV ASPVEVSSGG GGLGLRNPAD ITLNEYNRSE 660
GSSAEELLRR TPLKIRAPEM LTAPAGYGTE PCRMTLKQEP ETGY 704 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR000003; Retinoid-X_rcpt/HNF4.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00545; RETINOIDXR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.