CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Septin-10 
Protein Synonyms/Alias
  
Gene Name
 SEPT10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106FCPNVKLKAQTYELQubiquitination[1]
195TLDLLTMKNLDSKVNubiquitination[1]
200TMKNLDSKVNIIPVIubiquitination[1]
209NIIPVIAKADTVSKTubiquitination[1]
215AKADTVSKTELQKFKubiquitination[1]
269VGSMDEVKVGNKMVKubiquitination[1]
422EEIIAFSKKKATSEIubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). 
Sequence Annotation
 NP_BIND 73 80 GTP (By similarity).
 NP_BIND 209 217 GTP (By similarity).
 BINDING 128 128 GTP; via amide nitrogen (By similarity).
 BINDING 263 263 GTP; via amide nitrogen and carbonyl
 BINDING 278 278 GTP (By similarity).  
Keyword
 Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MASSEVARHL LFQSHMATKT TCMSSQGSDD EQIKRENIRS LTMSGHVGFE SLPDQLVNRS 60
IQQGFCFNIL CVGETGIGKS TLIDTLFNTN FEDYESSHFC PNVKLKAQTY ELQESNVQLK 120
LTIVNTVGFG DQINKEESYQ PIVDYIDAQF EAYLQEELKI KRSLFTYHDS RIHVCLYFIS 180
PTGHSLKTLD LLTMKNLDSK VNIIPVIAKA DTVSKTELQK FKIKLMSELV SNGVQIYQFP 240
TDDDTIAKVN AAMNGQLPFA VVGSMDEVKV GNKMVKARQY PWGVVQVENE NHCDFVKLRE 300
MLICTNMEDL REQTHTRHYE LYRRCKLEEM GFTDVGPENK PVSVQETYEA KRHEFHGERQ 360
RKEEEMKQMF VQRVKEKEAI LKEAERELQA KFEHLKRLHQ EERMKLEEKR RLLEEEIIAF 420
SKKKATSEIF HSQSFLATGS NLRKDKDRKK EPGCRFELLC IDVRACETNG GRKDAEKAPI 480
FCKTEVPEHR RSSSQANFIK KKN 503 
Gene Ontology
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW. 
Interpro
 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 
Pfam
 PF00735; Septin 
SMART
  
PROSITE
  
PRINTS