UniProt Accession

 F5H0W4_HUMAN; F5H0W4 

Genbank Protein ID

 AC046135 

Genbank Nucleotide ID

  

Protein Name

 Bridging integrator 2 

Protein Synonyms/Alias

  

Gene Name

 BIN2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	HKLYKDLKNFLSAVK	ubiquitination	[1]
119	RIAKRGRKLVDYDSA	ubiquitination	[2, 3]
224	SNKVFVVKGLSSSSR	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 539 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR003005; Amphiphysin.
 IPR004148; BAR_dom. 

Pfam

 PF03114; BAR 

SMART

 SM00721; BAR 

PROSITE

 PS51021; BAR 

PRINTS

 PR01251; AMPHIPHYSIN.