CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032383
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tax1-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 TAX1BP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
230RFSDATSKAHQLEEDubiquitination[1]
244DIVSVTHKAIEKETEubiquitination[1]
332LQLCLAEKENLQRTFubiquitination[2]
375QEVVFLAKELSDAVNubiquitination[2]
465RLQKQINKLSDQSANubiquitination[1, 2, 3, 4]
534MTKEIADKTEKYNKCubiquitination[5]
537EIADKTEKYNKCKQLubiquitination[5]
540DKTEKYNKCKQLLQDubiquitination[5]
549KQLLQDEKAKCNKYAubiquitination[1]
554DEKAKCNKYADELAKubiquitination[6]
561KYADELAKMELKWKEubiquitination[2, 3, 4, 5, 6, 7]
567AKMELKWKEQVKIAEubiquitination[2]
571LKWKEQVKIAENVKLubiquitination[5]
577VKIAENVKLELAEVQubiquitination[1]
719LEDSEDSKEDENVPTubiquitination[5]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 813 AA 
Protein Sequence
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 60
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 120
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 180
QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS 240
VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 300
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 360
EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 420
QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 480
TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 540
CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKLQ LAEKDKEISG 600
LISHLENLSR EKELKRSLEN PAERKMEGQN SQSPQCFKTC SEQNGYVLTL SNAQPVLQYG 660
NPYASQETRD GADGAFYPDE IQRPPVRVPS WGLEDNVVCS QPARNFSRPD GLEDSEDSKE 720
DENVPTAPDP PSQHLRGHGT GFCFDSSFDV HKKCPLCELM FPPNYDQSKF EEHVESHWKV 780
CPMCSEQFPP DYDQQVFERH VQTHFDQNVL NFD 813 
Gene Ontology
  
Interpro
 IPR012852; CoCoA.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF07888; CALCOCO1 
SMART
 SM00355; ZnF_C2H2 
PROSITE
  
PRINTS