CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028791
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HLA class I histocompatibility antigen, A-68 alpha chain 
Protein Synonyms/Alias
  
Gene Name
 HLA-A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145QQDAYDGKDYIALNEubiquitination[1, 2]
200RRYLENGKETLQRTDubiquitination[2]
267AGDGTFQKWASVVVPubiquitination[3]
292VQHEGLPKPLTLRWVubiquitination[3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF 60
DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ 120
RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW 180
RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT 240
WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWV 299 
Gene Ontology
 GO:0042612; C:MHC class I protein complex; IEA:InterPro.
 GO:0019882; P:antigen processing and presentation; IEA:InterPro.
 GO:0006955; P:immune response; IEA:InterPro. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2. 
Pfam
 PF07654; C1-set
 PF00129; MHC_I 
SMART
 SM00407; IGc1 
PROSITE
 PS50835; IG_LIKE
 PS00290; IG_MHC 
PRINTS
 PR01638; MHCCLASSI.