| Tag | Content |
|---|
| CPLM ID | CPLM-016422 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | High affinity choline transporter 1 |
Protein Synonyms/Alias | Hemicholinium-3-sensitive choline transporter; CHT; Solute carrier family 5 member 7 |
Gene Name | Slc5a7 |
Gene Synonyms/Alias | Cht1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 528 | HSEENMDKTILVRNE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. |
Sequence Annotation | CARBOHYD 301 301 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion transport; Membrane; Neurotransmitter biosynthesis; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 580 AA |
Protein Sequence | MSFHVEGLVA IILFYLLIFL VGIWAAWKTK NSGNPEERSE AIIVGGRDIG LLVGGFTMTA 60
TWVGGGYING TAEAVYGPGC GLAWAQAPIG YSLSLILGGL FFAKPMRSKG YVTMLDPFQQ 120
IYGKRMGGLL FIPALMGEMF WAAAIFSALG ATISVIIDVD VNISVIVSAL IAILYTLVGG 180
LYSVAYTDVV QLFCIFIGLW ISVPFALSHP AVTDIGFTAV HAKYQSPWLG TIESVEVYTW 240
LDNFLLLMLG GIPWQAYFQR VLSSSSATYA QVLSFLAAFG CLVMALPAIC IGAIGASTDW 300
NQTAYGYPDP KTKEEADMIL PIVLQYLCPV YISFFGLGAV SAAVMSSADS SILSASSMFA 360
RNIYQLSFRQ NASDKEIVWV MRITVLVFGA SATAMALLTK TVYGLWYLSS DLVYIIIFPQ 420
LLCVLFIKGT NTYGAVAGYI FGLFLRITGG EPYLYLQPLI FYPGYYSDKN GIYNQRFPFK 480
TLSMVTSFFT NICVSYLAKY LFESGTLPPK LDVFDAVVAR HSEENMDKTI LVRNENIKLN 540
ELAPVKPRQS LTLSSTFTNK EALLDVDSSP EGSGTEDNLQ 580 |
Gene Ontology | GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0043025; C:neuronal cell body; IDA:MGI. GO:0005886; C:plasma membrane; IDA:MGI. GO:0033265; F:choline binding; IDA:MGI. GO:0015220; F:choline transmembrane transporter activity; IMP:UniProtKB. GO:0005307; F:choline:sodium symporter activity; IEA:Compara. GO:0008292; P:acetylcholine biosynthetic process; IMP:UniProtKB. GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI. GO:0007271; P:synaptic transmission, cholinergic; IMP:MGI. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |