CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030245
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADAM metallopeptidase domain 17 
Protein Synonyms/Alias
 ADAM metallopeptidase domain 17 (Tumor necrosis factor, alpha, converting enzyme), isoform CRA_b; ADAM metallopeptidase domain 18 
Gene Name
 ADAM17 
Gene Synonyms/Alias
 ADAM18; hCG_23065 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
728SASVRIIKPFPAPQTubiquitination[1, 2]
753PSAPAAPKLDHQRMDubiquitination[1]
790PNSSTAAKSFEDLTDubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Disulfide bond; Hydrolase; Metal-binding; Metalloprotease; Protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 824 AA 
Protein Sequence
MRQSLLFLTS VVPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI QQHSVRKRDL 60
QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKVVVVD GKNESEYTVK WQDFFTGHVV 120
GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS 180
PKVCGYLKVD NEELLPKGLV DREPPEELVH RVKRRADPDP MKNTCKLLVV ADHRFYRYMG 240
RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 300
AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 360
HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 420
AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 480
SRVDEGEECD PGIMYLNNDT CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA 540
TCKGVSYCTG NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC 600
KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 660
INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHP SNVEMLSSMD 720
SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA APKLDHQRMD TIQEDPSTDS HMDEDGFEKD 780
PFPNSSTAAK SFEDLTDHPV TRSEKAASFK LQRQNRVDSK ETEC 824 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0048870; P:cell motility; IEA:Compara.
 GO:0002467; P:germinal center formation; IEA:Compara.
 GO:0051088; P:PMA-inducible membrane protein ectodomain proteolysis; IEA:Compara.
 GO:0051272; P:positive regulation of cellular component movement; IEA:Compara.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0033025; P:regulation of mast cell apoptotic process; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0048536; P:spleen development; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara. 
Interpro
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B.
 IPR002870; Peptidase_M12B_N. 
Pfam
 PF00200; Disintegrin
 PF01562; Pep_M12B_propep 
SMART
 SM00050; DISIN 
PROSITE
 PS50215; ADAM_MEPRO
 PS50214; DISINTEGRIN_2 
PRINTS