UniProt Accession

 GDIR2_MOUSE; Q61599; Q3TEB3 

Genbank Protein ID

 L07918; AK002516; AK169733; BC031763 

Genbank Nucleotide ID

 AAA61613.1; BAB22155.1; BAE41335.1; AAH31763.1 

Protein Name

 Rho GDP-dissociation inhibitor 2 

Protein Synonyms/Alias

 Rho GDI 2; D4; Rho-GDI beta 

Gene Name

 Arhgdib 

Gene Synonyms/Alias

 Gdid4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	PPPQKSLKELQEMDK	ubiquitination	[1]
123	KDIVSGLKYVQHTYR	acetylation	[2]
137	RTGMRVDKATFMVGS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 20 20 N6-acetyllysine (By similarity).
 MOD_RES 23 23 Phosphotyrosine (By similarity).
 MOD_RES 24 24 N6-acetyllysine (By similarity).
 MOD_RES 39 39 N6-acetyllysine (By similarity).
 MOD_RES 46 46 N6-acetyllysine (By similarity).
 MOD_RES 101 101 N6-acetyllysine (By similarity).
 MOD_RES 123 123 N6-acetyllysine (By similarity).
 MOD_RES 144 144 Phosphoserine (By similarity).
 MOD_RES 174 174 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; GTPase activation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005094; F:Rho GDP-dissociation inhibitor activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. 

Interpro

 IPR014756; Ig_E-set.
 IPR000406; Rho_GDI.
 IPR024792; RhoGDI_domain. 

Pfam

 PF02115; Rho_GDI 

SMART

  

PROSITE

  

PRINTS

 PR00492; RHOGDI.