CPLM-004405

Genbank Nucleotide ID

Protein Synonyms/Alias

Gal-1; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; S-Lac lectin 1

Mus musculus (Mouse)

Position	Peptide	Type	References
13	VASNLNLKPGECLKV	acetylation	[1, 2]
13	VASNLNLKPGECLKV	succinylation	[2]
19	LKPGECLKVRGEVAS	acetylation	[1, 2]
19	LKPGECLKVRGEVAS	succinylation	[2]
29	GEVASDAKSFVLNLG	acetylation	[1, 2, 3]
29	GEVASDAKSFVLNLG	succinylation	[2]
37	SFVLNLGKDSNNLCL	acetylation	[1]
37	SFVLNLGKDSNNLCL	ubiquitination	[4]
64	NTIVCNTKEDGTWGT	acetylation	[1]
108	LPDGHEFKFPNRLNM	acetylation	[1, 2, 3]
108	LPDGHEFKFPNRLNM	succinylation	[2]
108	LPDGHEFKFPNRLNM	ubiquitination	[4]
128	MAADGDFKIKCVAFE	acetylation	[1, 2, 3]

[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates (By similarity).

DOMAIN 4 135 Galectin.
REGION 45 49 Beta-galactoside binding (By similarity).
REGION 69 72 Beta-galactoside binding (By similarity).
BINDING 53 53 Beta-galactoside (By similarity).
BINDING 62 62 Beta-galactoside (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 29 29 N6-acetyllysine (By similarity).

Acetylation; Complete proteome; Extracellular matrix; Lectin; Reference proteome; Secreted.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0009986; C:cell surface; IEA:Compara.
GO:0005737; C:cytoplasm; IEA:Compara.
GO:0005615; C:extracellular space; IDA:MGI.
GO:0005634; C:nucleus; IEA:Compara.
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO:0005534; F:galactose binding; NAS:UniProtKB.
GO:0016936; F:galactoside binding; IEA:InterPro.
GO:0030395; F:lactose binding; IEA:Compara.
GO:0004871; F:signal transducer activity; IEA:Compara.
GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
GO:0007157; P:heterophilic cell-cell adhesion; NAS:UniProtKB.
GO:0033555; P:multicellular organismal response to stress; IEA:Compara.
GO:0045445; P:myoblast differentiation; IDA:MGI.
GO:0010812; P:negative regulation of cell-substrate adhesion; IEA:Compara.
GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
GO:0002317; P:plasma cell differentiation; IDA:MGI.
GO:0034120; P:positive regulation of erythrocyte aggregation; IEA:Compara.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
GO:0048678; P:response to axon injury; IEA:Compara.
GO:0042493; P:response to drug; IEA:Compara.
GO:0031295; P:T cell costimulation; IDA:MGI.

IPR008985; ConA-like_lec_gl_sf.
IPR013320; ConA-like_subgrp.
IPR015535; Galectin_1.
IPR001079; Galectin_CRD.

PF00337; Gal-bind_lectin

SM00908; Gal-bind_lectin
SM00276; GLECT