CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041085
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 
Protein Synonyms/Alias
  
Gene Name
 Samhd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
42APLEQPAKRPRCDGSubiquitination[1]
95NRGFREKKVLDIFRDubiquitination[1]
313GPPITPVKDSLWPYKubiquitination[1]
336LYEIVSNKRNGIDVDubiquitination[1]
378RICEVEYKVKEDKTYubiquitination[1]
498IECRNLYKYLGETQPubiquitination[1]
526PQEVAKAKPEKAPDVubiquitination[1]
651SCLQEVSKVKTCLKFacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 658 AA 
Protein Sequence
MDSLLGCGVS AAAREPVPRY LTSQPRVSEV AMQSAPLEQP AKRPRCDGSP RTPPSTPPAT 60
ANLSADDDFQ NTDLRTWEPE DVCSFLENRG FREKKVLDIF RDNKIAGSFL PFLDEDRLED 120
LGVSSLEERK KMIECIQQLS QSRIDLMKVF NDPIHGHIEF HPLLIRIIDT PQFQRLRYIK 180
QLGGGYYVFP GASHNRFEHS LGVGYLAGCL VRALAEKQPE LQISERDILC VQIAGLCHDL 240
GHGPFSHMFD GRFIPRARPE KKWKHEQGSI EMFEHLVNSN ELKLVMKNYG LVPEEDITFI 300
KEQIMGPPIT PVKDSLWPYK GRPATKSFLY EIVSNKRNGI DVDKWDYFAR DCHHLGIQNN 360
FDYKRFIKFA RICEVEYKVK EDKTYIRKVK HICSREKEVG NLYDMFHTRN CLHRRAYQHK 420
ISNLIDIMIT DAFLKADPYV EITGTAGKKF RISTAIDDME AFTKLTDNIF LEVLHSTDPQ 480
LSEAQSILRN IECRNLYKYL GETQPKREKI RKEEYERLPQ EVAKAKPEKA PDVELKAEDF 540
IVDVINVDYG MEDKNPIDRV HFYCKSNSKQ AVRINKEQVS QLLPEKFAEQ LIRVYCKKKD 600
GKSLDAAGKH FVQWCALRDF TKPQDGDIIA PLITPLKWNN KTSSCLQEVS KVKTCLKF 658 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:Compara.
 GO:0051607; P:defense response to virus; IEA:Compara.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0045088; P:regulation of innate immune response; IEA:Compara. 
Interpro
 IPR003607; HD/PDEase_dom.
 IPR006674; HD_domain.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2. 
Pfam
 PF01966; HD
 PF07647; SAM_2 
SMART
 SM00471; HDc
 SM00454; SAM 
PROSITE
 PS50105; SAM_DOMAIN 
PRINTS