| Tag | Content |
|---|
| CPLM ID | CPLM-013916 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 44 |
Protein Synonyms/Alias | Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; RICH-2 |
Gene Name | Arhgap44 |
Gene Synonyms/Alias | Rich2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 379 | KANHNNIKYLIKFLS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 (By similarity). |
Sequence Annotation | DOMAIN 14 249 BAR.
DOMAIN 255 445 Rho-GAP.
REGION 727 814 Interaction with BST2 (By similarity). |
Keyword | Alternative splicing; Complete proteome; GTPase activation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 814 AA |
Protein Sequence | MKKQFNRMRQ LANQTVGRAE KTEVLSEDLL QVEKRLELVK QVSHSTHKKL TACLQGQQGA 60
EADKRSKKLP LTTLAQCLVE GSAILGDDTL LGKMLKLCGE TEDKLAQELI HFELQVERDV 120
IEPLFLLAEV EIPNIQKQRK HLAKLVLDMD SSRTRWQQTS KSSGLSSSLQ PAGAKADALR 180
EEMEEAANRV EICRDQLSAD MYSFVAKEID YANYFQTLIE VQAEYHRKSL TLLQAVLPQI 240
KAQQEAWVEK PSFGKPLEEH LMISGREIAF PIEACVTMLL ECGMQEEGLF RVAPSASKLK 300
KLKAALDCCV VDVQEYSADP HAIAGALKSY LRELPEPLMT FELYDEWIQA SNIQEQDKRL 360
QALWNACEKL PKANHNNIKY LIKFLSKLSE YQDVNKMTPS NMAIVLGPNL LWPQSEGNIT 420
EMMTTVSLQI VGIIEPIIQH ADWFFPGEIE FNLTGSYGSP VHVNHNANYS SMPSPDMDPA 480
DRRQPEQARR PLSVATDNMM LEFYKKDGLR KIQSMGVRVM DTSWVARRGS SAGRKASCAP 540
PSMQPPAPPS ELAAPLPSPL PEQVPDSPAT PAPALSPSGA SLQPTPERPS VSKSKELSPG 600
SGQKGSPGSI QGTPCPGTQL GPQPAASPSQ LPADQSPHTL RKVSKKVAPI PPKVPFVQPG 660
TVSDQPVGQP SPVSLSPTPP STPSPYGLSY PPGYSMASGQ LSPASAPPLA SPSVFTSTLA 720
KSRPTPKPRQ RPTLPPPQPP SVSLSASSPQ STEHPMLDGM SPGESMSTDL VHFDVPSIHI 780
ELGSTLRLSP LEHARRHSAT DKRDSEEESE STAL 814 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |