CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low-density lipoprotein receptor-related protein 2 
Protein Synonyms/Alias
 LRP-2; Glycoprotein 330; gp330; Megalin 
Gene Name
 LRP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4045SMSDRPGKRCAAEGSacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. 
Sequence Annotation
 DOMAIN 26 64 LDL-receptor class A 1.
 DOMAIN 65 105 LDL-receptor class A 2.
 DOMAIN 106 144 LDL-receptor class A 3.
 DOMAIN 145 181 LDL-receptor class A 4.
 DOMAIN 182 219 LDL-receptor class A 5.
 DOMAIN 220 258 LDL-receptor class A 6.
 DOMAIN 264 308 LDL-receptor class A 7.
 DOMAIN 309 347 EGF-like 1.
 DOMAIN 348 386 EGF-like 2.
 REPEAT 436 478 LDL-receptor class B 1.
 REPEAT 479 521 LDL-receptor class B 2.
 REPEAT 522 568 LDL-receptor class B 3.
 REPEAT 569 612 LDL-receptor class B 4.
 REPEAT 613 653 LDL-receptor class B 5.
 DOMAIN 659 705 EGF-like 3.
 REPEAT 753 795 LDL-receptor class B 6.
 REPEAT 796 837 LDL-receptor class B 7.
 REPEAT 838 881 LDL-receptor class B 8.
 REPEAT 882 925 LDL-receptor class B 9.
 DOMAIN 970 1014 EGF-like 4.
 DOMAIN 1024 1062 LDL-receptor class A 8.
 DOMAIN 1065 1103 LDL-receptor class A 9.
 DOMAIN 1107 1145 LDL-receptor class A 10.
 DOMAIN 1147 1185 LDL-receptor class A 11.
 DOMAIN 1186 1224 LDL-receptor class A 12.
 DOMAIN 1228 1268 LDL-receptor class A 13.
 DOMAIN 1269 1307 LDL-receptor class A 14.
 DOMAIN 1310 1350 LDL-receptor class A 15.
 DOMAIN 1349 1389 EGF-like 5.
 DOMAIN 1390 1429 EGF-like 6; calcium-binding (Potential).
 REPEAT 1478 1520 LDL-receptor class B 10.
 REPEAT 1521 1563 LDL-receptor class B 11.
 REPEAT 1566 1609 LDL-receptor class B 12.
 REPEAT 1610 1654 LDL-receptor class B 13.
 REPEAT 1655 1695 LDL-receptor class B 14.
 DOMAIN 1700 1741 EGF-like 7.
 REPEAT 1790 1832 LDL-receptor class B 15.
 REPEAT 1833 1882 LDL-receptor class B 16.
 REPEAT 1883 1930 LDL-receptor class B 17.
 REPEAT 1931 1971 LDL-receptor class B 18.
 REPEAT 1972 2013 LDL-receptor class B 19.
 DOMAIN 2018 2059 EGF-like 8.
 REPEAT 2107 2156 LDL-receptor class B 20.
 REPEAT 2157 2201 LDL-receptor class B 21.
 REPEAT 2202 2245 LDL-receptor class B 22.
 REPEAT 2246 2289 LDL-receptor class B 23.
 REPEAT 2290 2331 LDL-receptor class B 24.
 DOMAIN 2342 2383 EGF-like 9.
 REPEAT 2431 2477 LDL-receptor class B 25.
 REPEAT 2478 2518 LDL-receptor class B 26.
 REPEAT 2519 2562 LDL-receptor class B 27.
 REPEAT 2563 2603 LDL-receptor class B 28.
 REPEAT 2604 2646 LDL-receptor class B 29.
 DOMAIN 2651 2693 EGF-like 10.
 DOMAIN 2698 2738 LDL-receptor class A 16.
 DOMAIN 2739 2777 LDL-receptor class A 17.
 DOMAIN 2778 2819 LDL-receptor class A 18.
 DOMAIN 2820 2861 LDL-receptor class A 19.
 DOMAIN 2862 2901 LDL-receptor class A 20.
 DOMAIN 2904 2945 LDL-receptor class A 21.
 DOMAIN 2946 2990 LDL-receptor class A 22.
 DOMAIN 2991 3029 LDL-receptor class A 23.
 DOMAIN 3030 3070 LDL-receptor class A 24.
 DOMAIN 3073 3110 LDL-receptor class A 25.
 DOMAIN 3111 3151 EGF-like 11.
 DOMAIN 3152 3192 EGF-like 12; calcium-binding (Potential).
 REPEAT 3239 3281 LDL-receptor class B 30.
 REPEAT 3282 3324 LDL-receptor class B 31.
 REPEAT 3333 3376 LDL-receptor class B 32.
 REPEAT 3377 3418 LDL-receptor class B 33.
 REPEAT 3419 3460 LDL-receptor class B 34.
 DOMAIN 3465 3509 EGF-like 13.
 DOMAIN 3510 3550 LDL-receptor class A 26.
 DOMAIN 3551 3591 LDL-receptor class A 27.
 DOMAIN 3592 3632 LDL-receptor class A 28.
 DOMAIN 3633 3673 LDL-receptor class A 29.
 DOMAIN 3676 3716 LDL-receptor class A 30.
 DOMAIN 3717 3756 LDL-receptor class A 31.
 DOMAIN 3757 3795 LDL-receptor class A 32.
 DOMAIN 3796 3834 LDL-receptor class A 33.
 DOMAIN 3840 3880 LDL-receptor class A 34.
 DOMAIN 3881 3922 LDL-receptor class A 35.
 DOMAIN 3926 3964 LDL-receptor class A 36.
 DOMAIN 3966 4006 EGF-like 14.
 DOMAIN 4007 4048 EGF-like 15; calcium-binding (Potential).
 REPEAT 4154 4196 LDL-receptor class B 35.
 REPEAT 4197 4240 LDL-receptor class B 36.
 REPEAT 4242 4283 LDL-receptor class B 37.
 DOMAIN 4330 4368 EGF-like 16.
 DOMAIN 4377 4411 EGF-like 17.
 REGION 4589 4602 Interaction with DAB2.
 MOTIF 4453 4462 SH3-binding (Potential).
 MOTIF 4521 4526 Endocytosis signal (Potential).
 MOTIF 4593 4598 NPXY motif.
 MOTIF 4598 4601 SH2-binding (Potential).
 MOTIF 4611 4622 SH3-binding (Potential).
 METAL 1208 1208 Calcium (By similarity).
 METAL 1210 1210 Calcium; via carbonyl oxygen (By
 METAL 1212 1212 Calcium (By similarity).
 METAL 1218 1218 Calcium (By similarity).
 METAL 1219 1219 Calcium (By similarity).
 MOD_RES 4463 4463 Phosphoserine (By similarity).
 MOD_RES 4471 4471 Phosphoserine (By similarity).
 CARBOHYD 159 159 N-linked (GlcNAc...) (Potential).
 CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
 CARBOHYD 300 300 N-linked (GlcNAc...) (Potential).
 CARBOHYD 341 341 N-linked (GlcNAc...) (Potential).
 CARBOHYD 388 388 N-linked (GlcNAc...) (Potential).
 CARBOHYD 463 463 N-linked (GlcNAc...) (Potential).
 CARBOHYD 866 866 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1064 1064 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1144 1144 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1186 1186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1327 1327 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1340 1340 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1383 1383 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1464 1464 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1496 1496 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1550 1550 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1675 1675 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1810 1810 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2055 2055 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2177 2177 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2224 2224 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2499 2499 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2547 2547 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2781 2781 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2809 2809 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2810 2810 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2947 2947 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2987 2987 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3125 3125 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3211 3211 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3257 3257 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3315 3315 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3355 3355 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3446 3446 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3564 3564 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3680 3680 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3978 3978 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4068 4068 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4327 4327 N-linked (GlcNAc...) (Potential).
 DISULFID 28 40 By similarity.
 DISULFID 35 53 By similarity.
 DISULFID 47 62 By similarity.
 DISULFID 67 80 By similarity.
 DISULFID 74 93 By similarity.
 DISULFID 87 103 By similarity.
 DISULFID 108 120 By similarity.
 DISULFID 115 133 By similarity.
 DISULFID 127 142 By similarity.
 DISULFID 147 157 By similarity.
 DISULFID 152 170 By similarity.
 DISULFID 164 179 By similarity.
 DISULFID 183 195 By similarity.
 DISULFID 190 208 By similarity.
 DISULFID 202 217 By similarity.
 DISULFID 222 234 By similarity.
 DISULFID 229 247 By similarity.
 DISULFID 241 256 By similarity.
 DISULFID 266 279 By similarity.
 DISULFID 273 292 By similarity.
 DISULFID 286 307 By similarity.
 DISULFID 312 321 By similarity.
 DISULFID 317 330 By similarity.
 DISULFID 332 346 By similarity.
 DISULFID 352 362 By similarity.
 DISULFID 358 371 By similarity.
 DISULFID 373 385 By similarity.
 DISULFID 663 674 By similarity.
 DISULFID 670 689 By similarity.
 DISULFID 691 704 By similarity.
 DISULFID 974 988 By similarity.
 DISULFID 984 998 By similarity.
 DISULFID 1000 1013 By similarity.
 DISULFID 1026 1038 By similarity.
 DISULFID 1033 1051 By similarity.
 DISULFID 1045 1060 By similarity.
 DISULFID 1067 1079 By similarity.
 DISULFID 1074 1092 By similarity.
 DISULFID 1086 1101 By similarity.
 DISULFID 1109 1121 By similarity.
 DISULFID 1116 1134 By similarity.
 DISULFID 1128 1143 By similarity.
 DISULFID 1149 1161 By similarity.
 DISULFID 1156 1174 By similarity.
 DISULFID 1168 1183 By similarity.
 DISULFID 1187 1200 By similarity.
 DISULFID 1194 1213 By similarity.
 DISULFID 1207 1222 By similarity.
 DISULFID 1230 1243 By similarity.
 DISULFID 1237 1256 By similarity.
 DISULFID 1250 1266 By similarity.
 DISULFID 1271 1283 By similarity.
 DISULFID 1278 1296 By similarity.
 DISULFID 1290 1305 By similarity.
 DISULFID 1312 1325 By similarity.
 DISULFID 1319 1338 By similarity.
 DISULFID 1332 1348 By similarity.
 DISULFID 1353 1364 By similarity.
 DISULFID 1360 1373 By similarity.
 DISULFID 1375 1388 By similarity.
 DISULFID 1394 1404 By similarity.
 DISULFID 1400 1413 By similarity.
 DISULFID 1415 1428 By similarity.
 DISULFID 1704 1713 By similarity.
 DISULFID 1709 1725 By similarity.
 DISULFID 1727 1740 By similarity.
 DISULFID 2022 2033 By similarity.
 DISULFID 2029 2043 By similarity.
 DISULFID 2045 2058 By similarity.
 DISULFID 2346 2357 By similarity.
 DISULFID 2353 2368 By similarity.
 DISULFID 2370 2382 By similarity.
 DISULFID 2655 2666 By similarity.
 DISULFID 2662 2675 By similarity.
 DISULFID 2677 2692 By similarity.
 DISULFID 2700 2712 By similarity.
 DISULFID 2707 2725 By similarity.
 DISULFID 2719 2736 By similarity.
 DISULFID 2741 2753 By similarity.
 DISULFID 2748 2766 By similarity.
 DISULFID 2760 2775 By similarity.
 DISULFID 2780 2793 By similarity.
 DISULFID 2788 2806 By similarity.
 DISULFID 2800 2817 By similarity.
 DISULFID 2822 2835 By similarity.
 DISULFID 2829 2848 By similarity.
 DISULFID 2842 2859 By similarity.
 DISULFID 2864 2876 By similarity.
 DISULFID 2871 2889 By similarity.
 DISULFID 2883 2899 By similarity.
 DISULFID 2906 2918 By similarity.
 DISULFID 2913 2931 By similarity.
 DISULFID 2925 2943 By similarity.
 DISULFID 2948 2965 By similarity.
 DISULFID 2955 2978 By similarity.
 DISULFID 2972 2988 By similarity.
 DISULFID 2993 3005 By similarity.
 DISULFID 3000 3018 By similarity.
 DISULFID 3012 3027 By similarity.
 DISULFID 3032 3044 By similarity.
 DISULFID 3039 3057 By similarity.
 DISULFID 3051 3068 By similarity.
 DISULFID 3075 3087 By similarity.
 DISULFID 3082 3100 By similarity.
 DISULFID 3094 3109 By similarity.
 DISULFID 3114 3126 By similarity.
 DISULFID 3122 3135 By similarity.
 DISULFID 3137 3150 By similarity.
 DISULFID 3156 3167 By similarity.
 DISULFID 3163 3176 By similarity.
 DISULFID 3178 3191 By similarity.
 DISULFID 3469 3480 By similarity.
 DISULFID 3476 3491 By similarity.
 DISULFID 3493 3508 By similarity.
 DISULFID 3512 3525 By similarity.
 DISULFID 3519 3538 By similarity.
 DISULFID 3532 3548 By similarity.
 DISULFID 3553 3565 By similarity.
 DISULFID 3560 3578 By similarity.
 DISULFID 3572 3589 By similarity.
 DISULFID 3594 3606 By similarity.
 DISULFID 3601 3619 By similarity.
 DISULFID 3613 3630 By similarity.
 DISULFID 3635 3647 By similarity.
 DISULFID 3642 3660 By similarity.
 DISULFID 3654 3671 By similarity.
 DISULFID 3678 3692 By similarity.
 DISULFID 3686 3705 By similarity.
 DISULFID 3699 3714 By similarity.
 DISULFID 3719 3732 By similarity.
 DISULFID 3727 3745 By similarity.
 DISULFID 3739 3754 By similarity.
 DISULFID 3759 3771 By similarity.
 DISULFID 3766 3784 By similarity.
 DISULFID 3778 3793 By similarity.
 DISULFID 3798 3810 By similarity.
 DISULFID 3805 3823 By similarity.
 DISULFID 3817 3832 By similarity.
 DISULFID 3842 3854 By similarity.
 DISULFID 3849 3867 By similarity.
 DISULFID 3861 3878 By similarity.
 DISULFID 3883 3896 By similarity.
 DISULFID 3891 3909 By similarity.
 DISULFID 3903 3920 By similarity.
 DISULFID 3928 3940 By similarity.
 DISULFID 3935 3953 By similarity.
 DISULFID 3947 3962 By similarity.
 DISULFID 3970 3979 By similarity.
 DISULFID 3975 3989 By similarity.
 DISULFID 3991 4005 By similarity.
 DISULFID 4011 4021 By similarity.
 DISULFID 4017 4030 By similarity.
 DISULFID 4032 4047 By similarity.
 DISULFID 4334 4342 By similarity.
 DISULFID 4338 4351 By similarity.
 DISULFID 4353 4367 By similarity.
 DISULFID 4381 4389 By similarity.
 DISULFID 4383 4399 By similarity.
 DISULFID 4401 4410 By similarity.  
Keyword
 3D-structure; Calcium; Coated pit; Complete proteome; Disease mutation; Disulfide bond; EGF-like domain; Endocytosis; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; SH3-binding; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4655 AA 
Protein Sequence
MDRGPAAVAC TLLLALVACL APASGQECDS AHFRCGSGHC IPADWRCDGT KDCSDDADEI 60
GCAVVTCQQG YFKCQSEGQC IPNSWVCDQD QDCDDGSDER QDCSQSTCSS HQITCSNGQC 120
IPSEYRCDHV RDCPDGADEN DCQYPTCEQL TCDNGACYNT SQKCDWKVDC RDSSDEINCT 180
EICLHNEFSC GNGECIPRAY VCDHDNDCQD GSDEHACNYP TCGGYQFTCP SGRCIYQNWV 240
CDGEDDCKDN GDEDGCESGP HDVHKCSPRE WSCPESGRCI SIYKVCDGIL DCPGREDENN 300
TSTGKYCSMT LCSALNCQYQ CHETPYGGAC FCPPGYIINH NDSRTCVEFD DCQIWGICDQ 360
KCESRPGRHL CHCEEGYILE RGQYCKANDS FGEASIIFSN GRDLLIGDIH GRSFRILVES 420
QNRGVAVGVA FHYHLQRVFW TDTVQNKVFS VDINGLNIQE VLNVSVETPE NLAVDWVNNK 480
IYLVETKVNR IDMVNLDGSY RVTLITENLG HPRGIAVDPT VGYLFFSDWE SLSGEPKLER 540
AFMDGSNRKD LVKTKLGWPA GVTLDMISKR VYWVDSRFDY IETVTYDGIQ RKTVVHGGSL 600
IPHPFGVSLF EGQVFFTDWT KMAVLKANKF TETNPQVYYQ ASLRPYGVTV YHSLRQPYAT 660
NPCKDNNGGC EQVCVLSHRT DNDGLGFRCK CTFGFQLDTD ERHCIAVQNF LIFSSQVAIR 720
GIPFTLSTQE DVMVPVSGNP SFFVGIDFDA QDSTIFFSDM SKHMIFKQKI DGTGREILAA 780
NRVENVESLA FDWISKNLYW TDSHYKSISV MRLADKTRRT VVQYLNNPRS VVVHPFAGYL 840
FFTDWFRPAK IMRAWSDGSH LLPVINTTLG WPNGLAIDWA ASRLYWVDAY FDKIEHSTFD 900
GLDRRRLGHI EQMTHPFGLA IFGEHLFFTD WRLGAIIRVR KADGGEMTVI RSGIAYILHL 960
KSYDVNIQTG SNACNQPTHP NGDCSHFCFP VPNFQRVCGC PYGMRLASNH LTCEGDPTNE 1020
PPTEQCGLFS FPCKNGRCVP NYYLCDGVDD CHDNSDEQLC GTLNNTCSSS AFTCGHGECI 1080
PAHWRCDKRN DCVDGSDEHN CPTHAPASCL DTQYTCDNHQ CISKNWVCDT DNDCGDGSDE 1140
KNCNSTETCQ PSQFNCPNHR CIDLSFVCDG DKDCVDGSDE VGCVLNCTAS QFKCASGDKC 1200
IGVTNRCDGV FDCSDNSDEA GCPTRPPGMC HSDEFQCQED GICIPNFWEC DGHPDCLYGS 1260
DEHNACVPKT CPSSYFHCDN GNCIHRAWLC DRDNDCGDMS DEKDCPTQPF RCPSWQWQCL 1320
GHNICVNLSV VCDGIFDCPN GTDESPLCNG NSCSDFNGGC THECVQEPFG AKCLCPLGFL 1380
LANDSKTCED IDECDILGSC SQHCYNMRGS FRCSCDTGYM LESDGRTCKV TASESLLLLV 1440
ASQNKIIADS VTSQVHNIYS LVENGSYIVA VDFDSISGRI FWSDATQGKT WSAFQNGTDR 1500
RVVFDSSIIL TETIAIDWVG RNLYWTDYAL ETIEVSKIDG SHRTVLISKN LTNPRGLALD 1560
PRMNEHLLFW SDWGHHPRIE RASMDGSMRT VIVQDKIFWP CGLTIDYPNR LLYFMDSYLD 1620
YMDFCDYNGH HRRQVIASDL IIRHPYALTL FEDSVYWTDR ATRRVMRANK WHGGNQSVVM 1680
YNIQWPLGIV AVHPSKQPNS VNPCAFSRCS HLCLLSSQGP HFYSCVCPSG WSLSPDLLNC 1740
LRDDQPFLIT VRQHIIFGIS LNPEVKSNDA MVPIAGIQNG LDVEFDDAEQ YIYWVENPGE 1800
IHRVKTDGTN RTVFASISMV GPSMNLALDW ISRNLYSTNP RTQSIEVLTL HGDIRYRKTL 1860
IANDGTALGV GFPIGITVDP ARGKLYWSDQ GTDSGVPAKI ASANMDGTSV KTLFTGNLEH 1920
LECVTLDIEE QKLYWAVTGR GVIERGNVDG TDRMILVHQL SHPWGIAVHD SFLYYTDEQY 1980
EVIERVDKAT GANKIVLRDN VPNLRGLQVY HRRNAAESSN GCSNNMNACQ QICLPVPGGL 2040
FSCACATGFK LNPDNRSCSP YNSFIVVSML SAIRGFSLEL SDHSETMVPV AGQGRNALHV 2100
DVDVSSGFIY WCDFSSSVAS DNAIRRIKPD GSSLMNIVTH GIGENGVRGI AVDWVAGNLY 2160
FTNAFVSETL IEVLRINTTY RRVLLKVTVD MPRHIVVDPK NRYLFWADYG QRPKIERSFL 2220
DCTNRTVLVS EGIVTPRGLA VDRSDGYVYW VDDSLDIIAR IRINGENSEV IRYGSRYPTP 2280
YGITVFENSI IWVDRNLKKI FQASKEPENT EPPTVIRDNI NWLRDVTIFD KQVQPRSPAE 2340
VNNNPCLENN GGCSHLCFAL PGLHTPKCDC AFGTLQSDGK NCAISTENFL IFALSNSLRS 2400
LHLDPENHSP PFQTINVERT VMSLDYDSVS DRIYFTQNLA SGVGQISYAT LSSGIHTPTV 2460
IASGIGTADG IAFDWITRRI YYSDYLNQMI NSMAEDGSNR TVIARVPKPR AIVLDPCQGY 2520
LYWADWDTHA KIERATLGGN FRVPIVNSSL VMPSGLTLDY EEDLLYWVDA SLQRIERSTL 2580
TGVDREVIVN AAVHAFGLTL YGQYIYWTDL YTQRIYRANK YDGSGQIAMT TNLLSQPRGI 2640
NTVVKNQKQQ CNNPCEQFNG GCSHICAPGP NGAECQCPHE GNWYLANNRK HCIVDNGERC 2700
GASSFTCSNG RCISEEWKCD NDNDCGDGSD EMESVCALHT CSPTAFTCAN GRCVQYSYRC 2760
DYYNDCGDGS DEAGCLFRDC NATTEFMCNN RRCIPREFIC NGVDNCHDNN TSDEKNCPDR 2820
TCQSGYTKCH NSNICIPRVY LCDGDNDCGD NSDENPTYCT THTCSSSEFQ CASGRCIPQH 2880
WYCDQETDCF DASDEPASCG HSERTCLADE FKCDGGRCIP SEWICDGDND CGDMSDEDKR 2940
HQCQNQNCSD SEFLCVNDRP PDRRCIPQSW VCDGDVDCTD GYDENQNCTR RTCSENEFTC 3000
GYGLCIPKIF RCDRHNDCGD YSDERGCLYQ TCQQNQFTCQ NGRCISKTFV CDEDNDCGDG 3060
SDELMHLCHT PEPTCPPHEF KCDNGRCIEM MKLCNHLDDC LDNSDEKGCG INECHDPSIS 3120
GCDHNCTDTL TSFYCSCRPG YKLMSDKRTC VDIDECTEMP FVCSQKCENV IGSYICKCAP 3180
GYLREPDGKT CRQNSNIEPY LIFSNRYYLR NLTIDGYFYS LILEGLDNVV ALDFDRVEKR 3240
LYWIDTQRQV IERMFLNKTN KETIINHRLP AAESLAVDWV SRKLYWLDAR LDGLFVSDLN 3300
GGHRRMLAQH CVDANNTFCF DNPRGLALHP QYGYLYWADW GHRAYIGRVG MDGTNKSVII 3360
STKLEWPNGI TIDYTNDLLY WADAHLGYIE YSDLEGHHRH TVYDGALPHP FAITIFEDTI 3420
YWTDWNTRTV EKGNKYDGSN RQTLVNTTHR PFDIHVYHPY RQPIVSNPCG TNNGGCSHLC 3480
LIKPGGKGFT CECPDDFRTL QLSGSTYCMP MCSSTQFLCA NNEKCIPIWW KCDGQKDCSD 3540
GSDELALCPQ RFCRLGQFQC SDGNCTSPQT LCNAHQNCPD GSDEDRLLCE NHHCDSNEWQ 3600
CANKRCIPES WQCDTFNDCE DNSDEDSSHC ASRTCRPGQF RCANGRCIPQ AWKCDVDNDC 3660
GDHSDEPIEE CMSSAHLCDN FTEFSCKTNY RCIPKWAVCN GVDDCRDNSD EQGCEERTCH 3720
PVGDFRCKNH HCIPLRWQCD GQNDCGDNSD EENCAPRECT ESEFRCVNQQ CIPSRWICDH 3780
YNDCGDNSDE RDCEMRTCHP EYFQCTSGHC VHSELKCDGS ADCLDASDEA DCPTRFPDGA 3840
YCQATMFECK NHVCIPPYWK CDGDDDCGDG SDEELHLCLD VPCNSPNRFR CDNNRCIYSH 3900
EVCNGVDDCG DGTDETEEHC RKPTPKPCTE YEYKCGNGHC IPHDNVCDDA DDCGDWSDEL 3960
GCNKGKERTC AENICEQNCT QLNEGGFICS CTAGFETNVF DRTSCLDINE CEQFGTCPQH 4020
CRNTKGSYEC VCADGFTSMS DRPGKRCAAE GSSPLLLLPD NVRIRKYNLS SERFSEYLQD 4080
EEYIQAVDYD WDPKDIGLSV VYYTVRGEGS RFGAIKRAYI PNFESGRNNL VQEVDLKLKY 4140
VMQPDGIAVD WVGRHIYWSD VKNKRIEVAK LDGRYRKWLI STDLDQPAAI AVNPKLGLMF 4200
WTDWGKEPKI ESAWMNGEDR NILVFEDLGW PTGLSIDYLN NDRIYWSDFK EDVIETIKYD 4260
GTDRRVIAKE AMNPYSLDIF EDQLYWISKE KGEVWKQNKF GQGKKEKTLV VNPWLTQVRI 4320
FHQLRYNKSV PNLCKQICSH LCLLRPGGYS CACPQGSSFI EGSTTECDAA IELPINLPPP 4380
CRCMHGGNCY FDETDLPKCK CPSGYTGKYC EMAFSKGISP GTTAVAVLLT ILLIVVIGAL 4440
AIAGFFHYRR TGSLLPALPK LPSLSSLVKP SENGNGVTFR SGADLNMDIG VSGFGPETAI 4500
DRSMAMSEDF VMEMGKQPII FENPMYSARD SAVKVVQPIQ VTVSENVDNK NYGSPINPSE 4560
IVPETNPTSP AADGTQVTKW NLFKRKSKQT TNFENPIYAQ MENEQKESVA ATPPPSPSLP 4620
AKPKPPSRRD PTPTYSATED TFKDTANLVK EDSEV 4655 
Gene Ontology
 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005768; C:endosome; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0006486; P:protein glycosylation; TAS:ProtInc.
 GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0042359; P:vitamin D metabolic process; TAS:Reactome. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR026823; cEGF.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt.
 IPR019825; Lectin_legB_Mn/Ca_BS.
 IPR002919; TIL_dom. 
Pfam
 PF12662; cEGF
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS