CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044611
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein SCO1 homolog, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 SCO1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89GDSTRPSKPGPVSWKubiquitination[1]
133ERQRHIGKPLLGGPFubiquitination[1]
192YVKEFSPKLVGLTGTubiquitination[2, 3]
252YFGQNKRKGEIAASIubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 270 AA 
Protein Sequence
MAMLVLVPGR VMRPLGGQLW RFLPRGLEFW GPAEGTARVL LRQFCARQAE AWRASGRPGY 60
CLGTRPLSTA RPPPPWSQKG PGDSTRPSKP GPVSWKSLAI TFAIGGALLA GMKHVKKEKA 120
EKLEKERQRH IGKPLLGGPF SLTTHTGERK TDKDYLDSIT TLPDLTPLFI SIDPERDTKE 180
AIANYVKEFS PKLVGLTGTR EEVDQVARAY RVYYSPGPKD EDEDYIVDHT IIMYLIGPDG 240
EFLDYFGQNK RKGEIAASIA THMRPYRKKS 270 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0006878; P:cellular copper ion homeostasis; IEA:InterPro.
 GO:0006825; P:copper ion transport; IEA:InterPro.
 GO:0008535; P:respiratory chain complex IV assembly; IEA:InterPro. 
Interpro
 IPR003782; SCO1/SenC.
 IPR017276; Synth_of_cyt-c-oxidase_Sco1/2.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF02630; SCO1-SenC 
SMART
  
PROSITE
  
PRINTS