CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023218
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptopodin-2 
Protein Synonyms/Alias
 Genethonin-2; Myopodin 
Gene Name
 SYNPO2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
688TGILQEAKRRSTTKPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Has an actin-binding and actin-bundling activity (By similarity). 
Sequence Annotation
 DOMAIN 6 88 PDZ.  
Keyword
 Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1093 AA 
Protein Sequence
MGTGDFICIS MTGGAPWGFR LQGGKEQKQP LQVAKIRNQS KASGSGLCEG DEVVSINGNP 60
CADLTYPEVI KLMESITDSL QMLIKRPSSG ISEALISENE NKNLEHLTHG GYVESTTLQI 120
RPATKTQCTE FFLAPVKTEV PLAENQRSGP DCAGSLKEET GPSYQRAPQM PDSQRGRVAE 180
ELILREKVEA VQPGPVVELQ LSLSQERHKG ASGPLVALPG AEKSKSPDPD PNLSHDRIVH 240
INSIPTNEKA DPFLRSSKII QISSGRELRV IQESEAGDAG LPRVEVILDC SDRQKTEGCR 300
LQAGKECVDS PVEGGQSEAP PSLVSFAVSS EGTEQGEDPR SEKDHSRPHK HRARHARLRR 360
SESLSEKQVK EAKSKCKSIA LLLTDAPNPN SKGVLMFKKR RRRARKYTLV SYGTGELERE 420
ADEEEEGDKE DTCEVAFLGA SESEVDEELL SDVDDNTQVV NFDWDSGLVD IEKKLNRGDK 480
MEMLPDTTGK GALMFAKRRE RMDQITAQKE EDKVGGTPSR EQDAAQTDGL RTTTSYQRKE 540
EESVRTQSSV SKSYIEVSHG LGHVPQQNGF SGTSETANIQ RMVPMNRTAK PFPGSVNQPA 600
TPFSPTRNMT SPIADFPAPP PYSAVTPPPD AFSRGVSSPI AGPAQPPPWP QPAPWSQPAF 660
YDSSERIASR DERISVPAKR TGILQEAKRR STTKPMFTFK EPKVSPNPEL LSLLQNSEGK 720
RGTGAGGDSG PEEDYLSLGA EACNFMQSSS AKQKTPPPVA PKPAVKSSSS QPVTPVSPVW 780
SPGVAPTQPP AFPTSNPSKG TVVSSIKIAQ PSYPPARPAS TLNVAGPFKG PQAAVASQNY 840
TPKPTVSTPT VNAVQPGAVG PSNELPGMSG RGAQLFAKRQ SRMEKYVVDS DTVQAHAARA 900
QSPTPSLPAS WKYSSNVRAP PPVAYNPIHS PSYPLAALKS QPSAAQPSKM GKKKGKKPLN 960
ALDVMKHQPY QLNASLFTFQ PPDAKDGLPQ KSSVKVNSAL AMKQALPPRP VNAASPTNVQ 1020
ASSVYSVPAY TSPPSFFAEA SSPVSASPVP VGIPTSPKQE SASSSYFVAP RPKFSAKKSG 1080
VTIQESGRSL SLPGRSVPPP ISTSPWVYQP TYSYSSKPTD GLEKANKRPT PWEAAAKSPL 1140
GLVDDAFQPR NIQESIVANV VSAARRKVLP GPPEDWNERL SYIPQTQKAY MGSCGRQEYN 1200
VTANNNMSTT SQYGSQLPYA YYRQASRNDS AIMSMETRSD YCLPVADYNY NPHPRGWRRQ 1260
T 1261 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:LIFEdb.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0030018; C:Z disc; ISS:UniProtKB.
 GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.
 GO:0051371; F:muscle alpha-actinin binding; ISS:UniProtKB. 
Interpro
 IPR001478; PDZ. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS