CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014564
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase RNF213 
Protein Synonyms/Alias
 ALK lymphoma oligomerization partner on chromosome 17; Mysterin; RING finger protein 213 
Gene Name
 RNF213 
Gene Synonyms/Alias
 ALO17; C17orf27; KIAA1554; KIAA1618; MYSTR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
461GEEFGESKWDSNICEubiquitination[1]
551YYDIVYMKPHGRLQKubiquitination[1]
558KPHGRLQKVMNHITDubiquitination[1]
645YLWQHLKKHVVPLPDubiquitination[1]
654VVPLPDGKSTDFLPVubiquitination[1]
796LLQFMREKQHLLSIDubiquitination[1]
1016DMEWRLTKEEPLSQIubiquitination[1]
1034CNSCWDTKGLEDSVAubiquitination[1]
1042GLEDSVAKTFEKCIIubiquitination[1]
1107LLTLADVKHVFRLCGubiquitination[1]
1118RLCGTDEKILANVTEubiquitination[1]
1128ANVTEDAKRLIAVADubiquitination[1]
1162LELIIKHKNQFLDIWubiquitination[1]
1200REELLLLKKEKRCVDubiquitination[1]
1211RCVDSLLKMCGNVKHubiquitination[1]
1272QVQEMAGKIDLLRDSubiquitination[1]
1337PSYRKFIKLHQDLKSubiquitination[1]
1386QDQRDWIKDRVEQIKubiquitination[1]
1393KDRVEQIKEYHHLHQubiquitination[1]
1453NQELIQAKKLLQDISubiquitination[1]
1454QELIQAKKLLQDISEubiquitination[1]
1465DISEARCKGLQALSLubiquitination[1]
1474LQALSLRKEFICWVRubiquitination[1]
1569ARNLEWLKTVNESHGubiquitination[1]
1601IYVIQAPKGGQKISPubiquitination[1]
1635EYSLEEVKELLNKLMubiquitination[1]
1648LMLMSGKKDRNNTEVubiquitination[1]
1767YLSTELRKQPPSDAAubiquitination[1]
1782LTMLSFIKSNCTLRDubiquitination[1]
2020AGHYRVPKQTLSAAAubiquitination[1]
2047SERAGVGKSLYVKRLubiquitination[1]
2052VGKSLYVKRLHDKMKubiquitination[1]
2059KRLHDKMKMQLNVKNubiquitination[1]
2065MKMQLNVKNVPLKTIubiquitination[1]
2070NVKNVPLKTIRLIDPubiquitination[1]
2178SFLDIFPKVTCRPPKubiquitination[1]
2185KVTCRPPKEVIDMELubiquitination[1]
2416PFNVDFDKLPRHKKLubiquitination[1]
2475MGETGCGKTRLIKFLubiquitination[1]
2480CGKTRLIKFLSDLRRubiquitination[1]
2496GTNADTIKLVKVHGGubiquitination[1]
2499ADTIKLVKVHGGTTAubiquitination[1]
2578AACNPYRKHSEEMICubiquitination[1]
2677ASQGFMRKTEDECSFubiquitination[1]
2762AIARFFPKPYDDSRLubiquitination[1]
2819IPLFLVGKPGSSKSLubiquitination[1]
2828GSSKSLAKTIVADAMubiquitination[1]
2849SDLFRSLKQVHLVSFubiquitination[1]
2907DSPKMPLKTLHPLLEubiquitination[1]
2926EDDPAPHKKVGFVGIubiquitination[1]
2927DDPAPHKKVGFVGISubiquitination[1]
2942NWALDPAKMNRGIFVubiquitination[1]
2964TELIESAKGICSSDIubiquitination[1]
2986GYFASFAKAYETVCKubiquitination[1]
2997TVCKRQDKEFFGLRDubiquitination[1]
3017KMVFAAAKASNRKPSubiquitination[1]
3022AAKASNRKPSPQDIAubiquitination[1]
3039VLRNFSGKDDIQALDubiquitination[1]
3068VSPMQLIKQNIFGPSubiquitination[1]
3077NIFGPSQKVPGGEQEubiquitination[1]
3208EEKDVVYKHFPIPLIubiquitination[1]
3231DINTVLEKWQKSIVEubiquitination[1]
3298LTEELHQKVSEEAKSubiquitination[1]
3304QKVSEEAKSILLNCAubiquitination[1]
3420NCLTNTAKCKILIFQubiquitination[1]
3566ESSEKVGKETSELGGubiquitination[1]
3641RLSVFLKKQEESQFHubiquitination[1]
3787DAEGLPKKFVDIFQQubiquitination[1]
3848WSCTRKLKAASEAPEubiquitination[1]
3925MLTRNTLKPSPQAWLubiquitination[1]
4006EHVFLLDKCLRENSDubiquitination[1]
4015LRENSDVKTHGPFEAubiquitination[1]
4031MRTLCECKETASKTLubiquitination[1]
4036ECKETASKTLSRFGIubiquitination[1]
4054SICLGDAKDPVCLPCubiquitination[1]
4164QRHCEHTKSLSPFNDubiquitination[1]
4175PFNDVVDKTPVIRSVubiquitination[1]
4255EEEGRFLKAYSPASRubiquitination[1]
4305GPEMAKEKQCYLQQVubiquitination[1]
4313QCYLQQVKQFCIRVEubiquitination[1]
4346EFVQGLSKPGRPHQWubiquitination[1]
4361VFPKDVVKQQGLRQDubiquitination[1]
4384LVYGDEYKALRDAVAubiquitination[1]
4392ALRDAVAKAVLECKPubiquitination[1]
4398AKAVLECKPLGIKTAubiquitination[1]
4403ECKPLGIKTALKACKubiquitination[1]
4451EQCEAVSKFIGECKIubiquitination[1]
4457SKFIGECKILSPPDIubiquitination[1]
4544LAQARRWKGLERVHWubiquitination[1]
4596RDGFHLVKDKADRTQubiquitination[1]
4720FDTELSTKEMRNNWEubiquitination[1]
4728EMRNNWEKEIAAVISubiquitination[1]
4743PELEHLDKTLPTMNNubiquitination[1]
4756NNLISQDKRISSNPVubiquitination[1]
4765ISSNPVAKIIYGDPVubiquitination[1]
4823ILWHFLQKEAELRLVubiquitination[1]
4831EAELRLVKFLPEILAubiquitination[1]
4845ALQRDLVKQFQNVQQubiquitination[1]
4864SIRGFLSKHSSDGLRubiquitination[1]
4949EIVYAVEKLSKENNSubiquitination[1]
4952YAVEKLSKENNSYSVubiquitination[1]
5004VQEFDLEKIQRQIVSubiquitination[1]
5017VSRFLQGKPRLSLKGubiquitination[1]
5023GKPRLSLKGIPTLVYubiquitination[1]
5046LFMDIKNKMAQDSLPubiquitination[1]
5144EQLLRLHKEPFGEISubiquitination[1]
5155GEISSRYKADLSPENubiquitination[1]
5191EMIILKLKNPQTQTEubiquitination[1]
5250WKTAAVLKWNREMR*ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity. 
Sequence Annotation
 ZN_FING 3997 4036 RING-type.
 MOD_RES 217 217 Phosphoserine.
 MOD_RES 1258 1258 Phosphoserine.  
Keyword
 Alternative splicing; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Ligase; Metal-binding; Phosphoprotein; Proto-oncogene; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5207 AA 
Protein Sequence
MECPSCQHVS KEETPKFCSQ CGERLPPAAP IADSENNNST MASASEGEME CGQELKEEGG 60
PCLFPGSDSW QENPEEPCSK ASWTVQEGAT SEVLVDAAVD LISDEWEAAN AIPSKRRKQD 120
AAPLEAASVP SADCEQSKKK KRKKKKKGNK SASSELASLP LSPASPCHLT LLSNPWPQDT 180
ALPHSQAQQS GPTGQPSQPP GTATTPLEGD GLSAPTEVGD SPLQAQALGE AGVATGSEAQ 240
SSPQFQDHTE GEDQDASIPS GGRGLSQEGT GPPTSAGEGH SRTEDAAQEL LLPESKGGSS 300
EPGTELQTTE QQAGASASMA VDAVAEPANA VKGAGKEMKE KTQRMKQPPA TTPPFKTHCQ 360
EAETKTKDEM AAAEEKVGKN EQGEPEDLKK PEGKNRSAAA VKNEKEQKNQ EADVQEVKAS 420
TLSPGGGVTV FFHAIISLHF PFNPDLHKVF IRGGEEFGES KWDSNICELH YTRDLGHDRV 480
LVEGIVCISK KHLDKYIPYK YVIYNGESFE YEFIYKHQQK KGEYVNRCLF IKSSLLGSGD 540
WHQYYDIVYM KPHGRLQKVM NHITDGPRKD LVKGKQIAAA LMLDSTFSIL QTWDTINLNS 600
FFTQFEQFCF VLQQPMIYEG QAQLWTDLQY REKEVKRYLW QHLKKHVVPL PDGKSTDFLP 660
VDCPVRSKLK TGLIVLFVVE KIELLLEGSL DWLCHLLTSD ASSPDEFHRD LSHILGIPQS 720
WRLYLVNLCQ RCMDTRTYTW LGALPVLHCC MELAPRHKDA WRQPEDTWAA LEGLSFSPFR 780
EQMLDTSSLL QFMREKQHLL SIDEPLFRSW FSLLPLSHLV MYMENFIEHL GRFPAHILDC 840
LSGIYYRLPG LEQVLNTQDV QDVQNVQNIL EMLLRLLDTY RDKIPEEALS PSYLTVCLKL 900
HEAICSSTKL LKFYELPALS AEIVCRMIRL LSLVDSAGQR DETGNNSVQT VFQGTLAATK 960
RWLREVFTKN MLTSSGASFT YVKEIEVWRR LVEIQFPAEH GWKESLLGDM EWRLTKEEPL 1020
SQITAYCNSC WDTKGLEDSV AKTFEKCIIE AVSSACQSQT SILQGFSYSD LRKFGIVLSA 1080
VITKSWPRTA DNFNDILKHL LTLADVKHVF RLCGTDEKIL ANVTEDAKRL IAVADSVLTK 1140
VVGDLLSGTI LVGQLELIIK HKNQFLDIWQ LREKSLSPQD EQCAVEEALD WRREELLLLK 1200
KEKRCVDSLL KMCGNVKHLI QVDFGVLAVR HSQDLSSKRL NDTVTVRLST SSNSQRATHY 1260
HLSSQVQEMA GKIDLLRDSH IFQLFWREAA EPLSEPKEDQ EAAELLSEPE EESERHILEL 1320
EEVYDYLYQP SYRKFIKLHQ DLKSGEVTLA EIDVIFKDFV NKYTDLDSEL KIMCTVDHQD 1380
QRDWIKDRVE QIKEYHHLHQ AVHAAKVILQ VKESLGLNGD FSVLNTLLNF TDNFDDFRRE 1440
TLDQINQELI QAKKLLQDIS EARCKGLQAL SLRKEFICWV REALGGINEL KVFVDLASIS 1500
AGENDIDVDR VACFHDAVQG YASLLFKLDP SVDFSAFMKH LKKLWKALDK DQYLPRKLCD 1560
SARNLEWLKT VNESHGSVER SSLTLATAIN QRGIYVIQAP KGGQKISPDT VLHLILPESP 1620
GSHEESREYS LEEVKELLNK LMLMSGKKDR NNTEVERFSE VFCSVQRLSQ AFIDLHSAGN 1680
MLFRTWIAMA YCSPKQGVSL QMDFGLDLVT ELKEGGDVTE LLAALCRQME HFLDSWKRFV 1740
TQKRMEHFYL NFYTAEQLVY LSTELRKQPP SDAALTMLSF IKSNCTLRDV LRASVGCGSE 1800
AARYRMRRVM EELPLMLLSE FSLVDKLRII MEQSMRCLPA FLPDCLDLET LGHCLAHLAG 1860
MGGSPVERCL PRGLQVGQPN LVVCGHSEVL PAALAVYMQT PSQPLPTYDE VLLCTPATTF 1920
EEVALLLRRC LTLGSLGHKV YSLLFADQLS YEVARQAEEL FHNLCTQQHR EDYQLVMVCD 1980
GDWEHCYLPS AFSQHKVFVT PQAPLEAIQA YLAGHYRVPK QTLSAAAVFN DRLCVGIVAS 2040
ERAGVGKSLY VKRLHDKMKM QLNVKNVPLK TIRLIDPQVD ESRVLGALLP FLDAQYQKVP 2100
VLFHLDVTSS VQTGIWVFLF KLLILQYLMD INGKMWLRNP CHLYIVEILE RRTSVPSRSS 2160
SALRTRVPQF SFLDIFPKVT CRPPKEVIDM ELSALRSDTE PGMDLWEFCS ETFQRPYQYL 2220
RRFNQNQDLD TFQYQEGSVE GTPEECLQHF LFHCGVINPS WSELRNFARF LNYQLRDCEA 2280
SLFCNPSFIG DTLRGFKKFV VTFMIFMARD FATPSLHTSD QSPGKHMVTM DGVREEDLAP 2340
FSLRKRWESE PHPYVFFNDD HTTMTFIGFH LQPNINGSVD AISHLTGKVI KRDVMTRDLY 2400
QGLLLQRVPF NVDFDKLPRH KKLERLCLTL GIPQATDPDK TYELTTDNML KILAIEMRFR 2460
CGIPVIIMGE TGCGKTRLIK FLSDLRRGGT NADTIKLVKV HGGTTADMIY SRVREAENVA 2520
FANKDQHQLD TILFFDEANT TEAISCIKEV LCDHMVDGQP LAEDSGLHII AACNPYRKHS 2580
EEMICRLESA GLGYRVSMEE TADRLGSIPL RQLVYRVHAL PPSLIPLVWD FGQLSDVAEK 2640
LYIQQIVQRL VESISLDENG TRVITEVLCA SQGFMRKTED ECSFVSLRDV ERCVKVFRWF 2700
HEHSAMLLAQ LNAFLSKSSV SKNHTERDPV LWSLMLAIGV CYHASLEKKD SYRKAIARFF 2760
PKPYDDSRLL LDEITRAQDL FLDGVPLRKT IAKNLALKEN VFMMVVCIEL KIPLFLVGKP 2820
GSSKSLAKTI VADAMQGPAA YSDLFRSLKQ VHLVSFQCSP HSTPQGIIST FRQCARFQQG 2880
KDLQQYVSVV VLDEVGLAED SPKMPLKTLH PLLEDGCIED DPAPHKKVGF VGISNWALDP 2940
AKMNRGIFVS RGSPNETELI ESAKGICSSD ILVQDRVQGY FASFAKAYET VCKRQDKEFF 3000
GLRDYYSLIK MVFAAAKASN RKPSPQDIAQ AVLRNFSGKD DIQALDIFLA NLPEAKCSEE 3060
VSPMQLIKQN IFGPSQKVPG GEQEDAESRY LLVLTKNYVA LQILQQTFFE GDQQPEIIFG 3120
SGFPKDQEYT QLCRNINRVK ICMETGKMVL LLNLQNLYES LYDALNQYYV HLGGQKYVDL 3180
GLGTHRVKCR VHPNFRLIVI EEKDVVYKHF PIPLINRLEK HYLDINTVLE KWQKSIVEEL 3240
CAWVEKFINV KAHHFQKRHK YSPSDVFIGY HSDACASVVL QVIERQGPRA LTEELHQKVS 3300
EEAKSILLNC ATPDAVVRLS AYSLGGFAAE WLSQEYFHRQ RHNSFADFLQ AHLHTADLER 3360
HAIFTEITTF SRLLTSHDCE ILESEVTGRA PKPTLLWLQQ FDTEYSFLKE VRNCLTNTAK 3420
CKILIFQTDF EDGIRSAQLI ASAKYSVINE INKIRENEDR IFVYFITKLS RVGRGTAYVG 3480
FHGGLWQSVH IDDLRRSTLM VSDVTRLQHV TISQLFAPGD LPELGLEHRA EDGHEEAMET 3540
EASTSGEVAE VAEEAMETES SEKVGKETSE LGGSDVSILD TTRLLRSCVQ SAVGMLRDQN 3600
ESCTRNMRRV VLLLGLLNED DACHASFLRV SKMRLSVFLK KQEESQFHPL EWLAREACNQ 3660
DALQEAGTFR HTLWKRVQGA VTPLLASMIS FIDRDGNLEL LTRPDTPPWA RDLWMFIFSD 3720
TMLLNIPLVM NNERHKGEMA YIVVQNHMNL SENASNNVPF SWKIKDYLEE LWVQAQYITD 3780
AEGLPKKFVD IFQQTPLGRF LAQLHGEPQQ ELLQCYLKDF ILLTMRVSTE EELKFLQMAL 3840
WSCTRKLKAA SEAPEEEVSL PWVHLAYQRF RSRLQNFSRI LTIYPQVLHS LMEARWNHEL 3900
AGCEMTLDAF AAMACTEMLT RNTLKPSPQA WLQLVKNLSM PLELICSDEH MQGSGSLAQA 3960
VIREVRAQWS RIFSTALFVE HVLLGTESRV PELQGLVTEH VFLLDKCLRE NSDVKTHGPF 4020
EAVMRTLCEC KETASKTLSR FGIQPCSICL GDAKDPVCLP CDHVHCLRCL RAWFASEQMI 4080
CPYCLTALPD EFSPAVSQAH REAIEKHARF RQMCNSFFVD LVSTICFKDN APPEKEVIES 4140
LLSLLFVQKG RLRDAAQRHC EHTKSLSPFN DVVDKTPVIR SVILKLLLKY SFHDVKDYIQ 4200
EYLTLLKKKA FITEDKTELY MLFINCLEDS ILEKTSAYSR NDELNHLEEE GRFLKAYSPA 4260
SRGREPANEA SVEYLQEVAR IRLCLDRAAD FLSEPEGGPE MAKEKQCYLQ QVKQFCIRVE 4320
NDWHRVYLVR KLSSQRGMEF VQGLSKPGRP HQWVFPKDVV KQQGLRQDHP GQMDRYLVYG 4380
DEYKALRDAV AKAVLECKPL GIKTALKACK TPQSQQSAYF LLTLFREVAI LYRSHNASLH 4440
PTPEQCEAVS KFIGECKILS PPDISRFATS LVDNSVPLLR AGPSDSNLDG TVTEMAIHAA 4500
AVLLCGQNEL LEPLKNLAFS PATMAHAFLP TMPEDLLAQA RRWKGLERVH WYTCPNGHPC 4560
SVGECGRPME QSICIDCHAP IGGIDHKPRD GFHLVKDKAD RTQTGHVLGN PQRRDVVTCD 4620
RGLPPVVFLL IRLLTHLALL LGASQSSQAL INIIKPPVRD PKGFLQQHIL KDLEQLAKML 4680
GHSADETIGV VHLVLRRLLQ EQHQLSSRRL LNFDTELSTK EMRNNWEKEI AAVISPELEH 4740
LDKTLPTMNN LISQDKRISS NPVAKIIYGD PVTFLPHLPR KSVVHCSKIW SCRKRITVEY 4800
LQHIVEQKNG KERVPILWHF LQKEAELRLV KFLPEILALQ RDLVKQFQNV QQVEYSSIRG 4860
FLSKHSSDGL RQLLHNRITV FLSTWNKLRR SLETNGEINL PKDYCSTDLD LDTEFEILLP 4920
RRRGLGLCAT ALVSYLIRLH NEIVYAVEKL SKENNSYSVD AAEVTELHVI SYEVERDLTP 4980
LILSNCQYQV EEGRETVQEF DLEKIQRQIV SRFLQGKPRL SLKGIPTLVY RHDWNYEHLF 5040
MDIKNKMAQD SLPSSVISAI SGQLQSYSDA CEVLSVVEVT LGFLSTAGGD PNMQLNVYTQ 5100
DILQMGDQTI HVLKALNRCQ LKHTIALWQF LSAHKSEQLL RLHKEPFGEI SSRYKADLSP 5160
ENAKLLSTFL NQTGLDAFLL ELHEMIILKL KNPQTQTEER FRPQWSLRDT LVSYMQTKES 5220
EILPEMASQF PEEILLASCV SVWKTAAVLK WNREMR 5256 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016887; F:ATPase activity; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051865; P:protein autoubiquitination; IDA:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR027417; P-loop_NTPase.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00097; zf-C3HC4 
SMART
 SM00382; AAA
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS