UniProt Accession

 IDI_ECOLI; Q46822; Q2M9V2 

Genbank Protein ID

 AF119715; U28375; U00096; AP009048 

Genbank Nucleotide ID

 AAD26812.1; AAA83070.1; AAC75927.1; BAE76954.1 

Protein Name

 Isopentenyl-diphosphate Delta-isomerase 

Protein Synonyms/Alias

 IPP isomerase; IPP:DMAPP isomerase; Isopentenyl pyrophosphate isomerase 

Gene Name

 idi 

Gene Synonyms/Alias

 ygfV; b2889; JW2857 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
21	VPTGTLEKYAAHTAD	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). 

Sequence Annotation

 DOMAIN 30 164 Nudix hydrolase.
 ACT_SITE 67 67
 ACT_SITE 116 116
 METAL 25 25 Manganese.
 METAL 32 32 Manganese.
 METAL 67 67 Magnesium; via carbonyl oxygen.
 METAL 69 69 Manganese.
 METAL 87 87 Magnesium.
 METAL 114 114 Manganese.
 METAL 116 116 Manganese.
 BINDING 21 21 Substrate.
 BINDING 51 51 Substrate.
 BINDING 55 55 Substrate.
 BINDING 69 69 Substrate.
 BINDING 83 83 Substrate.
 BINDING 87 87 Substrate.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Isomerase; Isoprene biosynthesis; Magnesium; Manganese; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0004452; F:isopentenyl-diphosphate delta-isomerase activity; IDA:EcoCyc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015995; P:chlorophyll biosynthetic process; IEA:HAMAP.
 GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:HAMAP.
 GO:0015979; P:photosynthesis; IEA:HAMAP.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0006744; P:ubiquinone biosynthetic process; IDA:EcoCyc. 

Interpro

 IPR011876; IsopentenylPP_isomerase_typ1.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX 

PRINTS