UniProt Accession

 B4DS64_HUMAN; B4DS64 

Genbank Protein ID

 AP002360; AK299594; CH471076 

Genbank Nucleotide ID

 BAG61526.1; EAW74992.1 

Protein Name

 52 kDa repressor of the inhibitor of the protein kinase 

Protein Synonyms/Alias

 Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor), isoform CRA_b; cDNA FLJ56857, highly similar to 52 kDa repressor of the inhibitor of theprotein kinase 

Gene Name

 PRKRIR 

Gene Synonyms/Alias

 hCG_2017355 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
428	EQHLKALKCLSLVPS	ubiquitination	[1]
479	IKWKHRGKDIELPST	acetylation	[2]
479	IKWKHRGKDIELPST	ubiquitination	[1]
530	ENGRKRLKAYLRNTL	ubiquitination	[1]
572	YIKLYTSKSELPTDN	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 586 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 

Interpro

 IPR025398; DUF4371.
 IPR008906; HATC.
 IPR012337; RNaseH-like_dom. 

Pfam

 PF05699; Dimer_Tnp_hAT
 PF14291; DUF4371 

SMART

  

PROSITE

  

PRINTS