UniProt Accession

 B7Z3I9_HUMAN; B7Z3I9 

Genbank Protein ID

 AL137066; AK295945 

Genbank Nucleotide ID

 BAH12225.1 

Protein Name

 Delta-aminolevulinic acid dehydratase 

Protein Synonyms/Alias

  

Gene Name

 ALAD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
196	GPFRDAAKSSPAFGD	ubiquitination	[1]
235	GADMLMVKPGMPYLD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 ACT_SITE 182 182 Schiff-base intermediate with substrate
 ACT_SITE 235 235 Schiff-base intermediate with substrate
 METAL 105 105 Zinc 1; catalytic (By similarity).
 METAL 107 107 Zinc 1; catalytic (By similarity).
 METAL 114 114 Zinc 2 (By similarity).
 METAL 115 115 Zinc 1; catalytic (By similarity).
 METAL 206 206 Zinc 2 (By similarity).
 BINDING 192 192 Substrate 1 (By similarity).
 BINDING 204 204 Substrate 1 (By similarity).
 BINDING 262 262 Substrate 2 (By similarity).
 BINDING 301 301 Substrate 2 (By similarity).  

Keyword

 Complete proteome; Lyase; Porphyrin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004655; F:porphobilinogen synthase activity; IEA:EC.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR001731; Porphobilinogen_synth. 

Pfam

 PF00490; ALAD 

SMART

 SM01004; ALAD 

PROSITE

 PS00169; D_ALA_DEHYDRATASE 

PRINTS

 PR00144; DALDHYDRTASE.