CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010016
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Aspartate--tRNA ligase 
Protein Synonyms/Alias
 Aspartyl-tRNA synthetase; AspRS 
Gene Name
 aspS 
Gene Synonyms/Alias
 MPN_046; MP108 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
281FNRFGSDKPDLRYGFacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MNLDNAKCFK QRVFIGNLTS EHLNKTVTIA GWVKRIKKLG ELNFVIVGDK TNTIQVTCKN 60
KEQVKYLTRE DLVIVKGKLK RLDSVRFEIT NPTITLFAKS KTPPLIIEDK TDALEEVRLR 120
YRYLDLRRPV MQKRLALRHK VTLAVRNWLD QMGFIEVETP TLTKSTPEGA RDFLVPARIR 180
EHSFYALPQS PQIYKQLLMV GGTEKYFQIA HVYRDEDSRK DRQPEHTQID LEVAFYTKEM 240
VMDLIQRLFV DVFRQVLNIK LKKPFPVLKF AEAFNRFGSD KPDLRYGFEL EDCTDLFQDS 300
PNQFTNLINA GGIVGGIQLP NLYLDEVSFK ALRKLAKDNG VSLEFYSDKA SSLKQPLDLP 360
LAGTILLVAH KSKTQAWTAL GAIRNELKYH LNLVKPNQYS FCWIVDFPLY EFDEKEQKWV 420
SAHNMFSNPQ PQWLVNFENH KAEALSEQYD LVLNGFELGS GSIRIHDPEV QTRLMQSLGV 480
DPQQFGFVME AYQYGAPVHA GMGLGLDRLM MIINNVDNIR EVMAFPKNAQ GIEMHTNAPD 540
QVDIKDITTI WSKHPVK 557 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004815; F:aspartate-tRNA ligase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006422; P:aspartyl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR004364; aa-tRNA-synt_II.
 IPR018150; aa-tRNA-synt_II-like.
 IPR006195; aa-tRNA-synth_II.
 IPR004524; Asp-tRNA-ligase_IIb_bac/mt.
 IPR002312; Asp/Asn-tRNA-synth_IIb.
 IPR004115; GAD_dom.
 IPR012340; NA-bd_OB-fold.
 IPR004365; NA-bd_OB_tRNA-helicase. 
Pfam
 PF00152; tRNA-synt_2
 PF01336; tRNA_anti 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR01042; TRNASYNTHASP.