CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 426 
Protein Synonyms/Alias
  
Gene Name
 ZNF426 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23PVCLHEEKTPAGRIVubiquitination[1]
181HDCNQYGKDFLTLCEubiquitination[1]
195EKTSTGEKLSEFNQSubiquitination[1]
204SEFNQSEKIFSLTPNubiquitination[1, 2]
222QRTSTQEKSFECSHCubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 42 112 KRAB.
 ZN_FING 146 174 C2H2-type 1; atypical.
 ZN_FING 224 246 C2H2-type 2.
 ZN_FING 280 302 C2H2-type 3.
 ZN_FING 308 330 C2H2-type 4.
 ZN_FING 336 358 C2H2-type 5.
 ZN_FING 364 386 C2H2-type 6.
 ZN_FING 392 414 C2H2-type 7.
 ZN_FING 420 442 C2H2-type 8.
 ZN_FING 448 470 C2H2-type 9.
 ZN_FING 476 498 C2H2-type 10.
 ZN_FING 504 526 C2H2-type 11.
 ZN_FING 532 554 C2H2-type 12.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 554 AA 
Protein Sequence
MAAADLSHGH YLSGDPVCLH EEKTPAGRIV ADCLTDCYQD SVTFDDVAVD FTQEEWTLLD 60
STQRSLYSDV MLENYKNLAT VGGQIIKPSL ISWLEQEESR TVQGGVLQGW EMRLETQWSI 120
LQQDFLRGQT SIGIQLEGKH NGRELCDCEQ CGEVFSEHSC LKTHVRTQST GNTHDCNQYG 180
KDFLTLCEKT STGEKLSEFN QSEKIFSLTP NIVYQRTSTQ EKSFECSHCG KSFINESYLQ 240
AHMRTHNGEK LYEWRNYGPG FIDSTSLSVL IETLNAKKPY KCKECGKGYR YPAYLSIHMR 300
THTGEKPYEC KECGKAFNYS NSFQIHGRTH TGEKPYVCKE CGKAFTQYSG LSMHVRSHSG 360
DKPYECKECG KSFLTSSRLI QHIRTHTGEK PFVCVECGKA FAVSSNLSGH LRTHTEEKAC 420
ECKICGKVFG YPSCLNNHMR THSAQKPYTC KECGKAFNYS THLKIHMRIH TGEKPYECKQ 480
CGKAFSHSSS FQIHERTHTG EKPYECKECG KAFTCSSSFR IHEKTHTEEK PYKCQQCGKA 540
YSHPRSLRRH EQIH 554 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS