CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Epha2 
Protein Synonyms/Alias
  
Gene Name
 Epha2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
640LKSSSGKKEIPVAIKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 977 AA 
Protein Sequence
MKLRAAGFCL ALLWGCALAA AAAQGKEAVL FSFNVEAGGL DVQSHPSCTQ WDLMQNIMND 60
MPIYMYSVCN VVSGDQDNWL RTNWVYREEA ERIFIELKFT VRDCNSFPGG ASSCKETFNL 120
YYAESDVDYG TNFQKRQFTK IDTIAPDEIT VSSDFEARNV KLNVEERMVG PLTRKGFYLA 180
FQDIGACVAL LSVRVYYKKC PEMLQSLARF PETIAVAVSD AQPLATVAGT CVDHAVVPYG 240
GEGPLMHCTV DGEWLVPIGQ CLCQEGYEKV EDACQACSPG FFKSEASESP CLQCPEHTLP 300
STEGATSCQC EEGYFRAPED PLSMPCTRPP SAPHYLTAIG MGAKVELRWT APQDTGGRKD 360
IVYSVTCEQC WPESGECGSC EASVQYSEPP QALTRTSVTV SDLEPHMNYT FTVEARNGVS 420
DLVNSRSFRT ASVSINQTEP PKVRLEDRST TSLSVAWSIP VPQQSRVWKY EVTYRKKGDA 480
NSYNVHRTDG FSVTLDGLAP GTTYLVQVQA LTQEGQGAGS KVHEFQTLST EGSATMAVIG 540
GVAVGVVLLL VLAGIGFFIH RRRRNLRARQ SSEDVYFSKS EQLKPLKTYV DPHTYEDPNQ 600
AVLKFTTEIH PSCVSRQKVI GAGEFGEVYK GTLKSSSGKK EIPVAIKTLK AGYTEKQRVD 660
FLSEASIMGQ FSHHNIIRLE GVVSKYKPMM IITEYMENGA LDKFLREKDG EFSVLQLVGM 720
LRGIASGMKY LANMNYVHRD LAARNILVNS NLVCKVSDFG LSRVLEDDPE ATYTTSGGKI 780
PIRWTAPEAI SYRKFTSASD VWSYGIVMWE VMTYGERPYW ELSNHEVMKA INDGFRLPTP 840
MDCPSAIYQL MMQCWQQERS RRPKFADIVS ILDKLIRAPD SLKTLADFDP RVSIRLPSTS 900
GSEGVPFRTV SEWLESIKMQ QYTEHFMVAG YTAIEKVVQM SNDDIKRIGV RLPGHQKRIA 960
YSLLGLKDQV NTVGIPI 977 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005003; F:ephrin receptor activity; IEA:InterPro. 
Interpro
 IPR001090; Ephrin_rcpt_lig-bd_dom.
 IPR003961; Fibronectin_type3.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR013783; Ig-like_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016257; Tyr_kinase_ephrin_rcpt.
 IPR001426; Tyr_kinase_rcpt_V_CS. 
Pfam
 PF01404; Ephrin_lbd
 PF00041; fn3
 PF07714; Pkinase_Tyr
 PF00536; SAM_1 
SMART
 SM00615; EPH_lbd
 SM00060; FN3
 SM00454; SAM
 SM00219; TyrKc 
PROSITE
 PS51550; EPH_LBD
 PS50853; FN3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00790; RECEPTOR_TYR_KIN_V_1
 PS00791; RECEPTOR_TYR_KIN_V_2
 PS50105; SAM_DOMAIN 
PRINTS
 PR00109; TYRKINASE.