CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032146
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptidyl-prolyl cis-trans isomerase FKBP5 
Protein Synonyms/Alias
 cDNA FLJ57237, highly similar to FK506-binding protein 5 (EC 5.2.1.8) 
Gene Name
 FKBP5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25DIPIGIDKALEKMQRubiquitination[1]
163KAVECCDKALGLDSAubiquitination[2]
173GLDSANEKGLYRRGEubiquitination[2, 3, 4, 5]
197SAKGDFEKVLEVNPQubiquitination[3]
206LEVNPQNKAARLQISubiquitination[2, 4, 5]
262SEGVTNEKGTDSQAMubiquitination[6]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 278 AA 
Protein Sequence
MFDCRDVAFT VGEGEDHDIP IGIDKALEKM QREEQCILYL GPRYGFGEAG KPKFGIEPNA 60
ELIYEVTLKS FEKAKESWEM DTKEKLEQAA IVKEKGTVYF KGGKYMQAVI QYGKIVSWLE 120
MEYGLSEKES KASESFLLAA FLNLAMCYLK LREYTKAVEC CDKALGLDSA NEKGLYRRGE 180
AQLLMNEFES AKGDFEKVLE VNPQNKAARL QISMCQKKAK EHNERDRRIY ANMFKKFAEQ 240
DAKEEANKAM GKKTSEGVTN EKGTDSQAME EEKPEGHV 278 
Gene Ontology
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR023114; Elongated_TPR_rpt_dom.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00254; FKBP_C 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS