UniProt Accession

 SELS_MOUSE; Q9BCZ4; Q921S1; Q9DB55 

Genbank Protein ID

 AF335543; AK005204; BC011091 

Genbank Nucleotide ID

 AAK07659.1; BAB23882.1; AAH11091.1 

Protein Name

 Selenoprotein S 

Protein Synonyms/Alias

 SelS; Minor histocompatibility antigen H47; VCP-interacting membrane protein 

Gene Name

 Vimp 

Gene Synonyms/Alias

 H47; Sels 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
77	LEPDVVVKRQEALAA	ubiquitination	[1]
99	DLNAQVEKHKEKLRQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Selenocysteine; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 190 AA 

Protein Sequence

Gene Ontology

 GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:InterPro.
 GO:0034362; C:low-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:Compara.
 GO:0016209; F:antioxidant activity; IEA:Compara.
 GO:0008430; F:selenium binding; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IEA:Compara.
 GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Compara.
 GO:0006983; P:ER overload response; IEA:Compara.
 GO:0030433; P:ER-associated protein catabolic process; IEA:Compara.
 GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.
 GO:0032715; P:negative regulation of interleukin-6 production; IMP:BHF-UCL.
 GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IEA:Compara.
 GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:BHF-UCL.
 GO:0080164; P:regulation of nitric oxide metabolic process; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0051775; P:response to redox state; IEA:Compara.
 GO:0030970; P:retrograde protein transport, ER to cytosol; IEA:Compara. 

Interpro

 IPR009703; Selenoprotein_S. 

Pfam

 PF06936; Selenoprotein_S 

SMART

  

PROSITE

  

PRINTS