CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000851
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-synuclein 
Protein Synonyms/Alias
 Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP 
Gene Name
 Snca 
Gene Synonyms/Alias
 Syn 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
6**MDVFMKGLSKAKEubiquitination[1]
96AAATGFVKKDQMGKGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May be involved in the regulation of dopamine release and transport. 
Sequence Annotation
 REPEAT 20 30 1.
 REPEAT 31 41 2.
 REPEAT 42 56 3; approximate.
 REPEAT 57 67 4.
 REGION 20 67 4 X 11 AA tandem repeats of [EGS]-K-T-K-
 METAL 2 2 Copper (By similarity).
 METAL 50 50 Copper (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 125 125 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 129 129 Phosphoserine; by PLK2.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Copper; Cytoplasm; Direct protein sequencing; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 140 AA 
Protein Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 60
EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP 120
GSEAYEMPSE EGYQDYEPEA 140 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005856; C:cytoskeleton; IDA:MGI.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0043205; C:fibril; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0016234; C:inclusion body; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005640; C:nuclear outer membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0031092; C:platelet alpha granule membrane; IEA:Compara.
 GO:0005840; C:ribosome; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0043195; C:terminal bouton; IEA:Compara.
 GO:0050544; F:arachidonic acid binding; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005507; F:copper ion binding; ISS:UniProtKB.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Compara.
 GO:0008198; F:ferrous iron binding; IEA:Compara.
 GO:0042393; F:histone binding; IDA:UniProtKB.
 GO:0042802; F:identical protein binding; IDA:MGI.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0016491; F:oxidoreductase activity; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0008344; P:adult locomotory behavior; IGI:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0048148; P:behavioral response to cocaine; IEA:Compara.
 GO:0071280; P:cellular response to copper ion; IEA:Compara.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IMP:MGI.
 GO:0042416; P:dopamine biosynthetic process; IMP:MGI.
 GO:0006631; P:fatty acid metabolic process; IMP:MGI.
 GO:0060291; P:long-term synaptic potentiation; IMP:MGI.
 GO:0001774; P:microglial cell activation; IMP:MGI.
 GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IMP:MGI.
 GO:0007006; P:mitochondrial membrane organization; IMP:MGI.
 GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Compara.
 GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IEA:Compara.
 GO:0045920; P:negative regulation of exocytosis; IEA:Compara.
 GO:0035067; P:negative regulation of histone acetylation; IEA:Compara.
 GO:0031115; P:negative regulation of microtubule polymerization; IEA:Compara.
 GO:0032769; P:negative regulation of monooxygenase activity; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IGI:MGI.
 GO:0051622; P:negative regulation of norepinephrine uptake; IEA:Compara.
 GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara.
 GO:0051612; P:negative regulation of serotonin uptake; IEA:Compara.
 GO:0070495; P:negative regulation of thrombin receptor signaling pathway; IEA:Compara.
 GO:0032410; P:negative regulation of transporter activity; IEA:Compara.
 GO:0006638; P:neutral lipid metabolic process; IMP:MGI.
 GO:0006644; P:phospholipid metabolic process; IMP:MGI.
 GO:0045807; P:positive regulation of endocytosis; IEA:Compara.
 GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Compara.
 GO:0001956; P:positive regulation of neurotransmitter secretion; IDA:MGI.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:BHF-UCL.
 GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Compara.
 GO:0001921; P:positive regulation of receptor recycling; IEA:Compara.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0031648; P:protein destabilization; IEA:Compara.
 GO:0031623; P:receptor internalization; IEA:Compara.
 GO:0050812; P:regulation of acyl-CoA biosynthetic process; IDA:MGI.
 GO:0014059; P:regulation of dopamine secretion; IGI:MGI.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IMP:MGI.
 GO:0014048; P:regulation of glutamate secretion; IMP:MGI.
 GO:0040012; P:regulation of locomotion; IMP:MGI.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
 GO:0043030; P:regulation of macrophage activation; IMP:MGI.
 GO:0010517; P:regulation of phospholipase activity; IEA:Compara.
 GO:0042493; P:response to drug; IMP:MGI.
 GO:0034341; P:response to interferon-gamma; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0010040; P:response to iron(II) ion; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0032026; P:response to magnesium ion; IEA:Compara.
 GO:0050808; P:synapse organization; IGI:MGI.
 GO:0001963; P:synaptic transmission, dopaminergic; IMP:MGI.
 GO:0048488; P:synaptic vesicle endocytosis; IMP:UniProtKB. 
Interpro
 IPR001058; Synuclein.
 IPR002460; Synuclein_alpha. 
Pfam
 PF01387; Synuclein 
SMART
  
PROSITE
  
PRINTS
 PR01212; ASYNUCLEIN.
 PR01211; SYNUCLEIN.