CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042317
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chloride channel 7, isoform CRA_c 
Protein Synonyms/Alias
 H(+)/Cl(-) exchange transporter 7 
Gene Name
 CLCN7 
Gene Synonyms/Alias
 hCG_42716 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
64KEIPHNEKLLSLKYEubiquitination[1]
250TSLKRDFKIFEYFRRubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 901 AA 
Protein Sequence
MANVSKKVSW SGRDRDDEEA APLLRRTARP GGGTPLLNGA GPGAARQDMD PPHPFPKEIP 60
HNEKLLSLKY ESLDYDNSEN QLFLEEERRI NHTAFRTVEI KRWVICALIG ILTGLVACFI 120
DIVVENLAGL KYRVIKGNID KFTEKGGLSF SLLLWATLNA AFVLVGSVIV AFIEPVAAGS 180
GIPQIKCFLN GVKIPHVVRL KTLVIKVSGV ILSVVGGLAV GKEGPMIHSG SVIAAGISQG 240
RSTSLKRDFK IFEYFRRDTE KRDFVSAGAA AGVSAAFGAP VGGVLFSLEE GASFWNQFLT 300
WRIFFASMIS TFTLNFVLSI YHGNMWDLSS PGLINFGRFD SEKMAYTIHE IPVFIAMGVV 360
GGVLGAVFNA LNYWLTMFRI RYIHRPCLQV IEAVLVAAVT ATVAFVLIYS SRDCQPLQGG 420
SMSYPLQLFC ADGEYNSMAA AFFNTPEKSV VSLFHDPPGS YNPLTLGLFT LVYFFLACWT 480
YGLTVSAGVF IPSLLIGAAW GRLFGISLSY LTGAAIWADP GKYALMGAAA QLGGIVRMTL 540
SLTVIMMEAT SNVTYGFPIM LVLMTAKIVG DVFIEGLYDM HIQLQSVPFL HWEAPVTSHS 600
LTAREVMSTP VTCLRRREKV GVIVDVLSDT ASNHNGFPVV EHADDTQPAR LQGLILRSQL 660
IVLLKHKVFV ERSNLGLVQR RLRLKDFRDA YPRFPPIQSI HVSQDERECT MDLSEFMNPS 720
PYTVPQACVA PTGVQAVPGP GPAAPGGGGQ PQSGCRVGDQ EGPRQVPPGK ERLGGALAGP 780
DVRPSPAHNG HWRWHPGPSA FPPGVTGFSA QTMLPSSGNG EHPAAGRAGG RRGTDPLAGL 840
TLLWAVVSPL GASLRRPSLH SPRLGFFTSR DQLCVCDLPT GLSASWEPAA GPAPACLCPC 900
A 901 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro. 
Interpro
 IPR014743; Cl-channel_core.
 IPR001807; Cl-channel_volt-gated.
 IPR002249; Cl_channel-7.
 IPR000644; Cysta_beta_synth_core. 
Pfam
 PF00571; CBS
 PF00654; Voltage_CLC 
SMART
 SM00116; CBS 
PROSITE
  
PRINTS
 PR00762; CLCHANNEL.
 PR01118; CLCHANNEL7.