UniProt Accession

 TRA2A_HUMAN; Q13595 

Genbank Protein ID

 U53209; BC017094 

Genbank Nucleotide ID

 AAC50658.1; AAH17094.1 

Protein Name

 Transformer-2 protein homolog alpha 

Protein Synonyms/Alias

 TRA-2 alpha; TRA2-alpha; Transformer-2 protein homolog A 

Gene Name

 TRA2A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
174	FERIDDSKEAMERAN	ubiquitination	[1]
198	RVDYSITKRAHTPTP	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. 

Sequence Annotation

 DOMAIN 119 197 RRM.
 REGION 198 225 Linker.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 24 24 Phosphothreonine.
 MOD_RES 84 84 Phosphoserine.
 MOD_RES 86 86 Phosphoserine.
 MOD_RES 88 88 Phosphothreonine.
 MOD_RES 96 96 Phosphoserine.
 MOD_RES 98 98 Phosphoserine.
 MOD_RES 202 202 Phosphothreonine.
 MOD_RES 204 204 Phosphothreonine.
 MOD_RES 236 236 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000398; P:mRNA splicing, via spliceosome; IDA:UniProtKB. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS