| Tag | Content |
|---|
| CPLM ID | CPLM-016883 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Epsin-2 |
Protein Synonyms/Alias | EPS-15-interacting protein 2; Intersectin-EH-binding protein 2; Ibp2 |
Gene Name | Epn2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 188 | YSEQEYGKAGGSPAS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in the formation of clathrin-coated invaginations and endocytosis (By similarity). |
Sequence Annotation | DOMAIN 12 144 ENTH.
REPEAT 218 237 UIM 1.
REPEAT 255 274 UIM 2.
REPEAT 313 315 1.
REPEAT 325 327 2.
REPEAT 338 340 3.
REPEAT 352 354 4.
REPEAT 370 372 5.
REPEAT 387 389 6.
REPEAT 494 496 1.
REPEAT 508 510 2.
REPEAT 591 593 3.
REGION 313 389 6 X 3 AA repeats of [DE]-P-W.
REGION 494 593 3 X 3 AA repeats of N-P-F.
BINDING 8 8 Phosphatidylinositol lipid headgroup (By
BINDING 11 11 Phosphatidylinositol lipid headgroup (By
BINDING 25 25 Phosphatidylinositol lipid headgroup (By
BINDING 30 30 Phosphatidylinositol lipid headgroup (By
BINDING 63 63 Phosphatidylinositol lipid headgroup (By
BINDING 73 73 Phosphatidylinositol lipid headgroup (By
MOD_RES 173 173 Phosphoserine.
MOD_RES 182 182 Phosphoserine.
MOD_RES 192 192 Phosphoserine.
MOD_RES 195 195 Phosphoserine.
MOD_RES 442 442 Phosphothreonine.
MOD_RES 443 443 Phosphoserine.
MOD_RES 449 449 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endocytosis; Lipid-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 595 AA |
Protein Sequence | MTTSSIRRQM KNIVNNYSEA EIKVREATSN DPWGPSSSLM TEIADLTYNV VAFSEIMSMV 60
WKRLNDHGKN WRHVYKALTL LDYLIKTGSE RVAQQCRENI FAIQTLKDFQ YIDRDGKDQG 120
INVREKSKQL VALLKDEERL KVERVQALKT KERMAQVATG VGSNQITFGR GSSQPNLSTS 180
YSEQEYGKAG GSPASYHGST SPRVSSELEQ ARPQTSGEEE LQLQLALAMS REVAEQSSES 240
VQTARGSKEE RLRRGDDLRL QMALEESRRD TVKVPKKKEA KACCKPGSHS QQTTLLDLMD 300
ALPSSGPVTQ KTEPWSAGAS ANQTNPWGGT VAPSNITDPW PSFGTKPAAS VDPWGVPTTA 360
STQSVPKNSD PWAASQQPAS NAGKTTDAWG AAKPSSASGS FELFSNFNGT VKDDFSEFDN 420
LRTSKKPAES GASVPPQDSR TTSPDLFESQ SLTSASSKPS SARKTPESFL GPNAALVNLD 480
SLVTKPAPPA QSLNPFLAPG AAAPAPVNPF QVNQPQPLTL NQLRGSPVLG SSASFGSGPG 540
VETVAPMTSV APHSSVGASG SSLTPLGPTA MNMVGSVGIP PSAAQSTGTT NPFLL 595 |
Gene Ontology | GO:0030128; C:clathrin coat of endocytic vesicle; IEA:InterPro. GO:0008289; F:lipid binding; IEA:UniProtKB-KW. GO:0048568; P:embryonic organ development; IGI:MGI. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0001701; P:in utero embryonic development; IGI:MGI. GO:0007219; P:Notch signaling pathway; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |