CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007684
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho-GTPase-activating protein RGD2 
Protein Synonyms/Alias
  
Gene Name
 RGD2 
Gene Synonyms/Alias
 YFL047W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
179KSLKIQNKYEEDVARubiquitination[1]
332AKEIIQSKIGNDQGAubiquitination[1]
341GNDQGAAKIQAPHISubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Acts in signal transduction. Activates CDC42 and RHO5. 
Sequence Annotation
 DOMAIN 2 71 FCH.
 DOMAIN 218 298 DEP.
 DOMAIN 475 704 Rho-GAP.  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 714 AA 
Protein Sequence
MLSFCDYFWS EDLVSGLDVL FDRLYHGCEQ CDLFIQLFAS RMQFEVSHGR QLFGIEAGMD 60
NLKAVQEDED EGVTVSRALR GILQEMSQEG THHLTIASNI ESLVLQPFSK WCIEHRERIQ 120
YSEKTLLTNV NNFRKSKKYV GKLEKEYFNK CRQLEEFKRT HFNEDELANA MKSLKIQNKY 180
EEDVAREKDH RFFNRIAGID FDYKTMKETL QLLLTKLPKT DYKLPLISYS LSNTNNGGEI 240
TKFLLDHMSL KDIDQAETFG QDLLNLGFLK YCNGVGNTFV NSKKFQYQWK NTAYMFANVP 300
MPGSEEPTTG ESLISRFNNW DGSSAKEIIQ SKIGNDQGAA KIQAPHISDN ERTLFRMMDA 360
LAASDKKYYQ ECFKMDALRC SVEELLIDHL SFMEKCESDR LNAIKKATLD FCSTLGNKIS 420
SLRLCIDKML TLENDIDPTA DLLQLLVKYK TGSFKPQAIV YNNYYNPGSF QNFGVDLETR 480
CRLDKKVVPL IISSIFSYMD KIYPDLPNDK VRTSIWTDSV KLSLTHQLRN LLNKQQFHNE 540
GEIFDILSTS KLEPSTIASV VKIYLLELPD PLIPNDVSDI LRVLYLDYPP LVETALQNST 600
SSPENQQDDD NEEGFDTKRI RGLYTTLSSL SKPHIATLDA ITTHFYRLIK ILKMGENGNE 660
VADEFTVSIS QEFANCIIQS KITDDNEIGF KIFYDLLTHK KQIFHELKRQ NSKN 714 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005100; F:Rho GTPase activator activity; IDA:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IPI:SGD. 
Interpro
 IPR000591; DEP_dom.
 IPR001060; FCH_dom.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00610; DEP
 PF00611; FCH
 PF00620; RhoGAP 
SMART
 SM00049; DEP
 SM00055; FCH
 SM00324; RhoGAP 
PROSITE
 PS50186; DEP
 PS50133; FCH
 PS50238; RHOGAP 
PRINTS